F-18 FDG PET/CT metabolic tumor volume predicts overall survival in patients with disseminated epithelial ovarian cancer
| Autor: | P.P. Mainenti, Piernicola Pedicini, Daniela Capacchione, Giuseppe Guglielmi, Angela Venetucci, Giovanni Storto, Cesare Sirignano, Rosj Gallicchio, Anna Nardelli, Alessandra Pelagalli |
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| Přispěvatelé: | Gallicchio, Rosj, Nardelli, Anna, Venetucci, ANGELA ASSUNTA, Capacchione, Daniela, Pelagalli, Alessandra, Sirignano, Cesare, Mainenti, Pierpaolo, Pedicini, Piernicola, Guglielmi, Giuseppe, Storto, Giovanni |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty Survival PET/CT medicine.medical_treatment Standardized uptake value Kaplan-Meier Estimate Carcinoma Ovarian Epithelial 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Internal medicine medicine Overall survival Humans Radiology Nuclear Medicine and imaging In patient Epithelial ovarian cancer Neoplasms Glandular and Epithelial Carcinomatosi Survival analysis Ovarian Neoplasms PET-CT Chemotherapy business.industry Cytoreduction Surgical Procedures General Medicine Prognosis Tumor Burden 030220 oncology & carcinogenesis medicine.symptom business Glycolysis |
| Zdroj: | European Journal of Radiology. 93:107-113 |
| ISSN: | 0720-048X |
| Popis: | Objective We evaluated the prognostic impact of quantitative assessment by maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV) and tumour lesion glycolysis (TLG) on [F-18] FDG PET/CT for patients with peritoneal carcinomatosis from epithelial ovarian cancer (EOC). Methods Thirty-one patients with EOC underwent PET/CT for an early restaging after cytoreductive surgery, having been diagnosed with carcinomatosis (before chemotherapy). The SUVmax, MTV (cm 3 ; 42% threshold) and TLG (g) were registered on residual peritoneal lesions. The patients were followed up 20 ± 12 months thereafter. The PET/CT results were compared to overall survival (OS). Results The Kaplan-Meier survival analysis for the SUVmax did not reveal significant differences in OS (p = 0.48). The MTV survival analysis showed a significant higher OS in patients presenting with a higher tumour burden than those with less tumour burden (p = 0.01; 26 vs. 14 months), whereas TLG exhibited a similar trend though not significant (p = 0.06). Apart from chemo-resistance, the higher the MTV, the better will be the response to chemotherapy. Conclusions Quantitative assessment by MTV rather than by SUVmax and TLG on PET/CT may be helpful for stratifying patients who present with peritoneal carcinomatosis from EOC, in order to implement the appropriate therapeutic regimen. |
| Databáze: | OpenAIRE |
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