Cysteamine: a Potent and Specific Depletor of Pituitary Prolactin
| Autor: | W. J. Millard, S. M. Sagar, D. M. Landis, J. B. Martin, T. M. Badger |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
endocrine system Spiperone medicine.medical_specialty Cysteamine Receptors Dopamine Prolactin cell chemistry.chemical_compound Pituitary Gland Anterior In vivo Internal medicine medicine Animals Cells Cultured Multidisciplinary Dose-Response Relationship Drug Chemistry Domperidone Prolactin In vitro Rats Kinetics Endocrinology Dopamine receptor hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Science. 217:452-454 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.7089575 |
| Popis: | Cysteamine rapidly reduces the concentration of prolactin in pituitary tissue in vivo and in vitro. The effect is dose-dependent, reversible, and cannot be accounted for by prolactin release. Cysteamine does not appear to exert its effect through dopamine receptors and does not alter lactotrope morphology, as determined by electron microscopy. |
| Databáze: | OpenAIRE |
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