Randomized controlled trial comparing nasal intermittent positive pressure ventilation and nasal continuous positive airway pressure in premature infants after tracheal extubation
| Autor: | Flávio Adolfo Costa Vaz, Edna Maria de Albuquerque Diniz, M E J R Ceccon, Daniela Franco Rizzo Komatsu, Alexandre Archanjo Ferraro |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_treatment intermittent positive pressure ventilation infant respiratory distress syndrome Intermittent Positive-Pressure Ventilation premature law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law 030225 pediatrics medicine Humans 030212 general & internal medicine Continuous positive airway pressure Mechanical ventilation Respiratory Distress Syndrome Newborn lcsh:R5-920 business.industry Tracheal intubation Infant Newborn Apnea Gestational age General Medicine controlled and random clinical trials Respiratory failure Anesthesia Apgar Score Female Apgar score medicine.symptom lcsh:Medicine (General) business Ventilator Weaning Infant Premature continuous positive airway pressure |
| Zdroj: | Revista da Associação Médica Brasileira v.62 n.6 2016 Revista da Associação Médica Brasileira Associação Médica Brasileira (AMB) instacron:AMB Revista da Associação Médica Brasileira, Vol 62, Iss 6, Pp 568-574 |
| ISSN: | 0104-4230 |
| DOI: | 10.1590/1806-9282.62.06.568 |
| Popis: | Summary Objective: To analyze the frequency of extubation failure in premature infants using conventional mechanical ventilation (MV) after extubation in groups subjected to nasal intermittent positive pressure ventilation (nIPPV) and continuous positive airway pressure (nCPAP). Method: Seventy-two premature infants with respiratory failure were studied, with a gestational age (GA) ≤ 36 weeks and birth weight (BW) > 750 g, who required tracheal intubation and mechanical ventilation. The study was controlled and randomized in order to ensure that the members of the groups used in the research were chosen at random. Randomization was performed at the time of extubation using sealed envelopes. Extubation failure was defined as the need for re-intubation and mechanical ventilation during the first 72 hours after extubation. Results: Among the 36 premature infants randomized to nIPPV, six (16.6%) presented extubation failure in comparison to 11 (30.5%) of the 36 premature infants randomized to nCPAP. There was no statistical difference between the two study groups regarding BW, GA, classification of the premature infant, and MV time. The main cause of extubation failure was the occurrence of apnea. Gastrointestinal and neurological complications did not occur in the premature infants participating in the study. Conclusion: We found that, despite the extubation failure of the group of premature infants submitted to nIPPV being numerically smaller than in premature infants submitted to nCPAP, there was no statistically significant difference between the two modes of ventilatory support after extubation. |
| Databáze: | OpenAIRE |
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