A comparison of rat SPECT images obtained using (99m)Tc derived from 99Mo produced by an electron accelerator with that from a reactor
| Autor: | Carl K. Ross, J Lockwood, J T Harvey, R.G. Wells, Raphael Galea, G H Isensee, K Moore |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Materials science chemistry.chemical_element Electrons Electron Bone imaging Technetium Bone and Bones law.invention Rats Sprague-Dawley Nuclear magnetic resonance law Image Processing Computer-Assisted Animals Radiology Nuclear Medicine and imaging Irradiation Rat Anatomy Molybdenum Radioisotopes Tomography Emission-Computed Single-Photon Radiological and Ultrasound Technology Radiochemistry Particle accelerator Heart Organotechnetium Compounds Rats Bone scanning chemistry Cathode ray Particle Accelerators |
| Zdroj: | Physics in medicine and biology. 58(9) |
| ISSN: | 1361-6560 |
| Popis: | Recent shortages of molybdenum-99 ( 99 Mo) have led to an examination of alternate production methods that could contribute to a more robust supply. An electron accelerator and the photoneutron reaction were used to produce 99 Mo from which technetium-99m ( 99m Tc) is extracted. SPECT images of rat anatomy obtained using the accelerator-produced 99m Tc with those obtained using 99m Tc from a commercial generator were compared. Disks of 100 Mo were irradiated with x-rays produced by a 35 MeV electron beam to generate about 1110 MBq (30 mCi) of 99 Mo per disk. After target dissolution, a NorthStar ARSII unit was used to separate the 99m Tc, which was subsequently used to tag pharmaceuticals suitable for cardiac and bone imaging. SPECT images were acquired for three rats and compared to images for the same three rats obtained using 99m Tc from a standard reactor 99 Mo generator. The efficiency of 99 Mo– 99m Tc separation was typically greater than 90%. This study demonstrated the delivery of 99m Tc from the end of beam to the end user of approximately 30 h. Images obtained using the heart and bone scanning agents using reactor and linac-produced 99m Tc were comparable. High-power electron accelerators are an attractive option for producing 99 Mo on a national scale. (Some figures may appear in colour only in the online journal) |
| Databáze: | OpenAIRE |
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