Assessment of Tenascin-C Levels in Ventricular Noncompaction/Hypertrabeculation Patients: A Cross-Sectional Study
| Autor: | Seref Kul, Mehmet Eren, Aycan Esen Zencirci, Ahmet Ekmekci, Nurten Sayar, Servet Altay, Hale Yilmaz, Hatice Betül Erer, Ahu Sarbay Kemik, Dilaver Oz, Gonul Zeren, Tolga Sinan Güvenç |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Heart Defects Congenital Male medicine.medical_specialty Cross-sectional study Cardiomyopathy Sensitivity and Specificity Internal medicine medicine Humans Radiology Nuclear Medicine and imaging In patient Prospective cohort study Ultrasonography Ejection fraction biology business.industry Tenascin C Curve analysis Reproducibility of Results Tenascin medicine.disease Cross-Sectional Studies biology.protein Cardiology Biomarker (medicine) Female Cardiomyopathies Cardiology and Cardiovascular Medicine business Biomarkers |
| Popis: | Purpose Ventricular noncompaction/hypertrabeculation (NC/HT) is a rare form of congenital cardiomyopathy. We aimed to investigate the presence of serum tenascin-C (TN-C) in adult patients with NC/HT and evaluate its value. Methods and Results Serum TN-C levels were measured by ELISA in 50 NC/HT patients both with/without systolic dysfunction and in 23 normal controls. Systolic dysfunction was defined as ejection fraction (EF) ≤ 40. Mann–Whitney U-test and ROC curve analysis were done. Of 49 NC/HT patients, 24 (49%) patients had systolic dysfunction (mean age 36 ± 15) and 25 patients (51%) had normal systolic function (mean age 36 ± 17). The ages between groups were not different. The mean levels of serum TN-C in patients with or without systolic dysfunction were 26 ± 10 ng/mL and 26 ± 8 ng/mL respectively, compared to normal controls, 7 ± 2 ng/mL (P |
| Databáze: | OpenAIRE |
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