Anal squamous intraepithelial lesions and condyloma in HIV-infected heterosexual men, homosexual men and women: prevalence and associated factors
| Autor: | Dalila Benabderrahmane, Laurent Abramowitz, Francine Walker, Catherine Leport, Jean-Claude Soulé, Christine Jestin, Philippe Ravaud, Christophe Rioux, Xavier Duval, Elisabeth Bouvet |
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| Přispěvatelé: | Service d'hépato-gastro-entérologie, Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département d'épidémiologie, biostatistique et recherche clinique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Anatomie et cytologie pathologique, Service des maladies infectieuses et tropicales, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques (U738 / UMR_S738), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Gillet, Catherine |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
MESH: Sexual Behavior HIV Infections MESH: Anus Diseases MESH: Anus Neoplasms 0302 clinical medicine Odds Ratio Prevalence Immunology and Allergy 030212 general & internal medicine anal canal In Situ Hybridization MESH: Middle Aged MESH: Risk medicine.diagnostic_test MESH: Anal Canal Anal dysplasia Homosexuality MESH: HIV Infections Anal canal Middle Aged Anus Neoplasms MESH: Homosexuality 3. Good health Squamous intraepithelial lesion Infectious Diseases medicine.anatomical_structure Condylomata Acuminata 030220 oncology & carcinogenesis Female MESH: Heterosexuality Carcinoma in Situ Adult Risk medicine.medical_specialty Human papillomavirus anal cancer Sexual Behavior Immunology 03 medical and health sciences MESH: In Situ Hybridization MESH: Cross-Sectional Studies medicine Anal cancer Humans Risk factor Heterosexuality MESH: Prevalence Gynecology MESH: Carcinoma in Situ Anus Diseases MESH: Humans Papilloma business.industry Anoscopy HIV MESH: Adult Odds ratio medicine.disease MESH: Male MESH: Odds Ratio Cross-Sectional Studies anal dysplasia Dysplasia [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie MESH: Papilloma business MESH: Condylomata Acuminata MESH: Female condyloma |
| Zdroj: | AIDS AIDS, Lippincott, Williams & Wilkins, 2007, 21 (11), pp.1457-65. ⟨10.1097/QAD.0b013e3281c61201⟩ AIDS. Official journal of the international AIDS Society AIDS. Official journal of the international AIDS Society, 2007, 21 (11), pp.1457-65. ⟨10.1097/QAD.0b013e3281c61201⟩ |
| ISSN: | 0269-9370 1473-5571 |
| Popis: | International audience; OBJECTIVE: To assess the prevalence of and factors associated with squamous intraepithelial lesions and condyloma [human papillomavirus (HPV)-related lesions) in HIV-infected patients. DESIGN: A cross-sectional study in a tertiary-care university hospital conducted in 516 consecutive outpatients. INTERVENTION: A systematic examination for macroscopic HPV-related lesions through anoscopy with histological confirmation, evaluation of dysplasia and HPV typing. Sexual behaviours were assessed using a semi-directive questionnaire. RESULTS: Of 473 patients examined, (200 homosexual men, 123 heterosexual men, 150 women), 108 (23%) had histologically confirmed anal HPV-related lesions (36, 15 and 11% of the respective populations), including 51 (47%) with only endoanal localization. Among these 108 patients, histological dysplasia of grades I or II and grade III were noted in 59 and two patients, respectively, invasive endoanal cancer in one; three patients also had high-risk oncogenicity HPV without dysplasia. Independent identified associated factors of HPV-related condyloma were the number of incidents of sexual intercourse per month [odds ratio (OR) 1.04; 95% confidence interval (CI) 1.01-1.06], CD4 cell count below 200 x 10 cells/l (OR 3.22; 95% CI 1.37-7.60), history of anal HPV lesion (OR 4.57; 95% CI 2.13-9.81), and receptive anal intercourse (OR 2.30; 95% CI 1.11-4.77). The two latter factors remained associated with histological dysplasia (OR 2.82; 95% CI 1.38-5.76 for history of anal condyloma, and OR 4.29; 95% CI 2.18-8.44 for receptive anal intercourse). CONCLUSION: The high rate of condyloma and histological dysplasia seen argues for a systematic screening for these lesions in HIV-infected individuals. |
| Databáze: | OpenAIRE |
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