Changing serotype distribution and resistance patterns among pediatric nasopharyngeal pneumococci collected in Moscow, 2010–2017
| Autor: | Natalia Alyabieva, Nikolai Mayanskiy, Ekaterina Brzhozovskaya, Olga Ponomarenko, Anna Lazareva, Tatiana Kulichenko, Tatiana Savinova |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Serotype Veterinary medicine 030106 microbiology Population Erythromycin Microbial Sensitivity Tests Serogroup medicine.disease_cause Moscow 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Drug Resistance Multiple Bacterial Nasopharynx Streptococcus pneumoniae Prevalence medicine Humans Distribution (pharmacology) 030212 general & internal medicine education Retrospective Studies education.field_of_study Resistance pattern business.industry Infant General Medicine Anti-Bacterial Agents Bacterial Typing Techniques Infectious Diseases Child Preschool Carrier State Multilocus sequence typing business Multilocus Sequence Typing medicine.drug |
| Zdroj: | Diagnostic Microbiology and Infectious Disease. 94:385-390 |
| ISSN: | 0732-8893 |
| DOI: | 10.1016/j.diagmicrobio.2019.02.010 |
| Popis: | Serotype distribution and antimicrobial resistance were analyzed in 632 nasopharyngeal pneumococcal isolates collected at a single pediatric center in 2010-2017 before and following the introduction of the 13-valent pneumococcal conjugated vaccine (PCV13) in Russia in 2014. The mean prevalence of PCV13 serotypes was 77.7% in 2010-2015 with a significant decline to 58.5% in 2017, which was accompanied by an elevation in serotype 15B/C prevalence (15.1% in 2017), 66% and 26% of 15B/C-pneumococci related to ST1025 and ST1262, respectively. The rate of oxacillin, erythromycin, and clindamycin resistance has increased by 15-20 percentage points from 2010 to 2016, approaching a 40-45% prevalence in 2016. The resistance rates significantly increased over time only in a group of PCV13 serotypes. The growing resistance among serotype 14 pneumococci was associated with expansion of a multidrug-resistant clone of ST143. These results emphasize the need for close monitoring of the constantly changing pneumococcal population. |
| Databáze: | OpenAIRE |
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