Vaped Humectants in E-Cigarettes Are a Source of Phenols
| Autor: | Alan Shihadeh, Soha Talih, Ahmad El-Hellani, Rola Salman, Najat A. Saliba, Rachel El-Hage |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Catechol Chromatography Molecular Structure Vaping Extraction (chemistry) General Medicine Electronic Nicotine Delivery Systems 010501 environmental sciences Toxicology 01 natural sciences Article Aerosol 03 medical and health sciences chemistry.chemical_compound Phenols chemistry Yield (chemistry) Glycerol Humans Phenol Hydroxyquinone 030304 developmental biology 0105 earth and related environmental sciences |
| Zdroj: | Chem Res Toxicol |
| ISSN: | 1520-5010 0893-228X |
| DOI: | 10.1021/acs.chemrestox.0c00132 |
| Popis: | Electronic cigarettes (ECIGs) have always been promoted as safer alternatives to combustible cigarettes. However, a growing amount of literature shows that while ECIGs do not involve combustion-derived toxicants, thermal degradation of the main constituents of ECIG liquid produces toxicants such as carbonyls. In this study, we report the detection of phenolic compounds in ECIG aerosols using a novel analytical method. The introduced method relies on liquid-liquid extraction to separate phenols from the major constituents of ECIG aerosol: propylene glycol (PG) and vegetable glycerol (VG). Phenol emissions from ECIGs were tested at different powers, puff durations, PG/VG ratios, nicotine benzoate concentrations, and flow rates to assess the influence of these operating parameters on phenol formation. The performance metrics showed that the analytical method has high specificity and reliability to separate and quantify phenolic compounds in ECIG aerosols. Increasing power and puff duration significantly increased all phenol emissions, while flow rate had no significant effects. The phenol profile in the ECIG aerosol was dominated by the unsubstituted phenol that reached comparable levels to those of IQOS, combustible cigarettes, and waterpipe. In contrast, low levels of the more toxic phenolic compounds, like catechol and hydroxyquinone, were quantified in ECIG aerosols. Emission of toxicants is presented, for the first time in this study, as the yield per unit of time, or flux (μg/s), which is more suitable for interstudy and interproduct comparison. This work demonstrates a robust analytical method for isolating and quantifying phenol emissions in ECIG aerosols. Using this method, the study shows that phenols, which are not present in the simple solution of nicotine benzoate dissolved in mixtures of PG/VG, are formed upon vaping. Phenol emissions are independent of the nicotine benzoate concentration but significantly correlated with the PG/VG ratio. Emissions increased with power and puff duration, consistent with conditions that lead to a higher temperature and greater thermal degradation. |
| Databáze: | OpenAIRE |
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