Roles of hyaluronan in cardiovascular and nervous system disorders

Autor: Naoki Ishiguro, Hongyan Ding, Koji Kimata, Yoshihiro Nishida, Qiang Dong, Yanan Xie, Lisheng Zhuo
Rok vydání: 2019
Předmět:
0301 basic medicine
Nervous system
Aging
Multiple Sclerosis
Myocardial Infarction
Regulator
Cellular functions
Review
General Biochemistry
Genetics and Molecular Biology
Extracellular matrix
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Molecular size
Cell Movement
Seizures
Biological property
Hyaluronic acid
Animals
Humans
Medicine
Hyaluronic Acid
General Pharmacology
Toxicology and Pharmaceutics
Spinal Cord Injuries
integumentary system
General Veterinary
business.industry
Brain
Heart
Structural component
General Medicine
Atherosclerosis
Extracellular Matrix
Stroke
carbohydrates (lipids)
030104 developmental biology
medicine.anatomical_structure
chemistry
Cardiovascular Diseases
030220 oncology & carcinogenesis
Nervous System Diseases
business
Neuroscience
Biomarkers
Protein Binding
Signal Transduction
Zdroj: Journal of Zhejiang University-SCIENCE B. 20:428-436
ISSN: 1862-1783
1673-1581
Popis: Hyaluronan is a widely occurring extracellular matrix molecule, which is not only a supporting structural component, but also an active regulator of cellular functions. The chemophysical and biological properties of hyaluronan are greatly affected by its molecular size and several hyaluronan-binding proteins, making hyaluronan a fascinating molecule with great functional diversity. This review summarizes our current understanding of the roles of hyaluronan in cardiovascular and nervous system disorders, such as atherosclerosis, myocardial infarction, and stroke, with the aim to provide a foundation for future research and clinical trials.
Databáze: OpenAIRE
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