The Ability of Extracellular Vesicles to Induce a Pro-Inflammatory Host Response
| Autor: | Maike E. van Hezel, Nicole P. Juffermans, Rienk Nieuwland, Robin van Bruggen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Inflammatory response Host response Inflammation Review Adaptive Immunity 030204 cardiovascular system & hematology Biology Extracellular vesicles Catalysis Inorganic Chemistry Extracellular Vesicles 03 medical and health sciences 0302 clinical medicine Immune system Characterization methods medicine host response Animals Humans Physical and Theoretical Chemistry Blood Coagulation Molecular Biology Spectroscopy Immunity Cellular Organic Chemistry General Medicine Acquired immune system Computer Science Applications Cell biology 030104 developmental biology Host-Pathogen Interactions Immunology Drug delivery Inflammation Mediators medicine.symptom |
| Zdroj: | International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Extracellular vesicles (EVs) can modulate the host immune response, executing both pro- and anti-inflammatory effects. As EVs increasingly gain attention as potential carriers for targeted gene and drug delivery, knowledge on the effects of EVs on the host immune response is important. This review will focus on the ability of EVs to trigger a pro-inflammatory host response by activating target cells. The overall view is that EVs can augment an inflammatory response, thereby potentially contributing to organ injury. This pro-inflammatory potential of EVs may hamper its use for therapeutic drug delivery. Whether removal of EVs as a means to reduce a pro-inflammatory or pro-coagulant response during hyper-inflammatory conditions is beneficial remains to be determined. Prior to any proposed therapeutic application, there is a need for further studies on the role of EVs in physiology and pathophysiology using improved detection and characterization methods to elucidate the roles of EVs in inflammatory conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|