HIV incidence in the Estonian population in 2013 determined using the HIV-1 limiting antigen avidity assay

Autor: Soodla, P., Simmons, R., Huik, K., Pauskar, M., Jõgeda, E. -L., Rajasaar, H., Kallaste, E., Maimets, M., Avi, R., Murphy, G., Porter, K., Lutsar, I., Del Amo, Julia, Meyer, Laurence, Bucher, Heiner C., Chêne, Geneviève, Hamouda, Osamah, Pillay, Deenan, Prins, Maria, Rosinska, Magda, Sabin, Caroline, Touloumi, Giota, Olson, Ashley, Cartier, Andrea, Fradette, Lorraine, Walker, Sarah, Babiker, Abdel, De Luca, Andrea, Fisher, Martin, Muga, Roberto, Kelleher, Tony, Cooper, David, Grey, Pat, Finlayson, Robert, Bloch, Mark, Ramacciotti, Tim, Gelgor, Linda, Smith, Don, Zangerle, Robert, Gill, John, Dabis, Francois, Thiebaut, Rodolphe, Costagliola, Dominique, Guiguet, Marguerite, Vanhems, Philippe, Chaix, Marie-Laure, Ghosn, Jade, Boufassa, Faroudy, Meixenberger, Karolin, Bannert, Norbert, Bartmeyer, Barbara, Antoniadou, Anastasia, Chrysos, Georgios, Daikos, Georgios L., Pantazis, Nikos, Katsarou, Olga, Rezza, Giovanni, Dorrucci, Maria, Monforte, Antonella d'Arminio, Geskus, Ronald, van der Helm, Jannie, Schuitemaker, Hanneke, Sannes, Mette, Brubakk, Oddbjorn, Kran, Anne-Marte Bakken, Rosinska, Magdalena, Tor, Jordi, de Olalla, Patricia Garcia, Cayla, Joan, Moreno, Santiago, Monge, Susana, del Romero, Jorge, Pérez-Hoyos, Santiago, Sönnerborg, Anders, Günthard, Huldrych, Scherrer, Alexandra, Malyuta, Ruslan, Johnson, Anne, Phillips, Andrew, Morrison, Charles, Price, Matt A., Giaquinto, Carlo, Grarup, Jesper, Kirk, Ole, Bailey, Heather, Volny Anne, Alain, Panteleev, Alex, Thorne, Claire, Aboulker, Jean-Pierre, Albert, Jan, Asandi, Silvia, De Wit, Stéphane, Reiss, Peter, Gatell, José, Karpov, Igor, Ledergerber, Bruno, Møller, Claus, Rakhmanova, Aza, Rockstroh, Jürgen, Sandhu, Manjinder, Dedes, Nikos, Pizzuti, David, Faggion, Silvia, Raben, Dorthe, Schwimmer, Christine, Scott, Martin
Přispěvatelé: APH - Global Health, Infectious diseases, Epidemiology and Data Science, Experimental Immunology, APH - Aging & Later Life, Global Health
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
HIV Infections
Immunoenzyme Techniques
0302 clinical medicine
Epidemiology
Pharmacology (medical)
Prospective Studies
030212 general & internal medicine
media_common
Aged
80 and over

education.field_of_study
Transmission (medicine)
Incidence
Health Policy
Incidence (epidemiology)
virus diseases
Middle Aged
3. Good health
Infectious Diseases
Female
epidemiology
Viral load
Adult
Estonia
medicine.medical_specialty
Adolescent
030106 microbiology
Population
Eastern Europe
recent infection testing algorithm
Young Adult
recent HIV infection
03 medical and health sciences
Internal medicine
medicine
Humans
HIV serological assay
media_common.cataloged_instance
European union
Seroconversion
education
Aged
injecting drug users
Diagnostic Tests
Routine

business.industry
Public health
HIV
Immunology
HIV-1
business
Zdroj: HIV medicine, 19(1), 33-41. Wiley-Blackwell
ISSN: 1464-2662
DOI: 10.1111/hiv.12535
Popis: OBJECTIVES: Estonia has one the highest number of new HIV diagnoses in the European Union, mainly among injecting drug users and heterosexuals. Little is known of HIV incidence, which is crucial for limiting the epidemic. Using a recent HIV infection testing algorithm (RITA) assay, we aimed to estimate HIV incidence in 2013. METHODS: All individuals aged ≥18 years newly-diagnosed with HIV in Estonia January- December 2013, except blood donors and those undergoing antenatal screening, were included. Demographic and clinical data were obtained from the Estonian Health Board and the Estonian HIV-positive patient database. Serum samples were tested for recent infection using the LAg-avidity EIA assay. HIV incidence was estimated based on previously published methods. RESULTS: Of 69,115 tested subjects, 286 (0.41%) were newly-diagnosed with HIV with median age of 33 years (IQR: 28–42) and 65% male. Self-reported routes of HIV transmission were mostly heterosexual contact (n = 157, 53%) and injecting drug use (n = 62, 21%); 64 (22%) were with unknown risk group. Eighty two (36%) were assigned recent, resulting in estimated HIV incidence of 0.06%, corresponding to 642 new infections in 2013 among the non-screened population. Incidence was highest (1.48%) among people who inject drugs. CONCLUSIONS: These high HIV incidence estimates in Estonia call for urgent action of renewed targeted public health promotion and HIV testing campaigns.
Databáze: OpenAIRE