Evaluation of the Epidermal Growth Factor Receptor (EGFR) and c-erbB-2 in Superspreading-type and Penetrating-type Gastric Carcinoma
| Autor: | Motoshi Miyagi, Jinryo Takeda, Shojiro Yano, Keishiro Aoyagi, Kikuo Kohfuji, Kazuo Shirouzu, Naotaka Murakami |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male TGF alpha C erbb 2 medicine.medical_specialty Receptor ErbB-2 Gastric carcinoma Stomach Neoplasms Epidermal growth factor Internal medicine medicine Humans Epidermal growth factor receptor Autocrine signalling Gastric wall Aged Epidermal Growth Factor biology Chemistry General Medicine Middle Aged Transforming Growth Factor alpha Immunohistochemistry ErbB Receptors Endocrinology Cancer research biology.protein Female |
| Zdroj: | The Kurume Medical Journal. 48:197-200 |
| ISSN: | 1881-2090 0023-5679 |
| DOI: | 10.2739/kurumemedj.48.197 |
| Popis: | The expression of epidermal growth factor (EGF), epidermal growth factor receptor (EGFR), transforming growth factor alpha (TGF alpha), and of c-erbB-2 was immunohistochemically investigated in resected gastric carcinoma (in 39 cases of superspreading type and in 11 cases of penetrating type), to understand the differential biological features of these two types of gastric carcinoma. EGF, EGFR and c-erbB-2 positive cases were preferentially found in penetrating type rather than in superspreading type (p < 0.05, p < 0.01, and p < 0.05, respectively). The positive rates of EGFR and c-erbB-2 were significantly higher in submucosal gastric carcinoma than in intramucosal gastric carcinoma (p < 0.01, p < 0.05, respectively). These results suggested that the autocrine mechanism of the growth factors and the expression of c-erbB-2 were correlated to the degree of gastric wall invasion. |
| Databáze: | OpenAIRE |
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