Dietary medium-chain triacylglycerol prevents the postprandial rise of plasma triacylglycerols but induces hypercholesterolemia in primary hypertriglyceridemic subjects
| Autor: | Edna Regina Nakandakare, Ana Mp Lottenberg, Valéria S. Nunes, Eder C Quintao, J.C. Rocha, Marisa Passarelli, M Q T S Neves, Leiko Asakura |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Hypercholesterolemia Medicine (miscellaneous) Blood lipids chemistry.chemical_compound Internal medicine medicine Humans Triglycerides Hypertriglyceridemia Nutrition and Dietetics Chemistry Cholesterol Cholesterol HDL food and beverages Metabolism Fasting Middle Aged medicine.disease Dietary Fats Endocrinology Postprandial lipids (amino acids peptides and proteins) Composition (visual arts) Female Corn Oil Energy Intake Corn oil Lipoprotein |
| Zdroj: | The American journal of clinical nutrition. 71(3) |
| ISSN: | 0002-9165 |
| Popis: | BACKGROUND Previous studies showed divergent results concerning the influence of medium-chain triacylglycerol (MCT) on lipoprotein metabolism. OBJECTIVE The objective of this study was to compare the effects of MCT and corn oil on plasma lipids in primary hypertriglyceridemic patients. DESIGN Ten subjects ate different proportions of corn oil and MCT for 12 wk. The subjects first ate a low-fat diet for 2 wk and during the next 4 wk, corn oil was added as the sole source of fat. Thereafter, for 2-wk periods, the subjects were sequentially fed corn oil and MCT mixed in the following proportions: 3:1, 1:1, and 0:1. Fasting plasma total cholesterol, triacylglycerol, and HDL-cholesterol concentrations were measured at the end of each period. At the end of the 100%-corn oil and of the 100%-MCT periods, subjects were fed a test meal containing the respective oil (40 g fat/m(2) body surface area) and total cholesterol and triacylglycerols were measured at 2-h intervals over 8 h; fasting lipoprotein composition was also measured. RESULTS Compared with corn oil, MCT was associated with a higher mean (+/-SD) fasting total cholesterol concentration (6.39 +/- 1.14 compared with 5.51 +/- 0.98 mmol/L, respectively; P < 0. 05); non-HDL-cholesterol concentrations were also higher with MCT (5. 36 +/- 1.11 mmol/L) than with corn oil (4.51 +/- 0.92 mmol/L; P < 0. 005). In response to the liquid test meal, plasma total cholesterol did not change with either diet but triacylglycerols increased with the 100%-corn oil diet. CONCLUSIONS MCT prevents the risk of pancreatitis due to postprandial hypertriglyceridemia but has the inconvenience of raising total cholesterol concentrations in primary hypertriglyceridemic subjects. |
| Databáze: | OpenAIRE |
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