Metabolism of testosterone during weight loss in men with obesity
| Autor: | Koen Deventer, Frederique Van de Velde, Bruno Lapauw, Peter Van Eenoo, Tim Reyns, Wim Van Gansbeke, Tom Fiers, Yves Van Nieuwenhove, Jean-Marc Kaufman, Pieter Van Renterghem |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Longitudinal study Endocrinology Diabetes and Metabolism Urinary system Clinical Biochemistry Population medicine.disease_cause Biochemistry 03 medical and health sciences 0302 clinical medicine Endocrinology Sex hormone-binding globulin Weight loss Sex Hormone-Binding Globulin Internal medicine Weight Loss medicine Humans Testosterone Longitudinal Studies Obesity Prospective Studies education Molecular Biology education.field_of_study biology Gastric bypass surgery business.industry Hydroxysteroid Dehydrogenases Cell Biology Middle Aged medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis biology.protein Molecular Medicine medicine.symptom business |
| Zdroj: | The Journal of Steroid Biochemistry and Molecular Biology. 209:105851 |
| ISSN: | 0960-0760 |
| Popis: | Objective Men with obesity often have low total and, with increasing adiposity, also low free testosterone (T) levels, which can partially restore during weight loss. Although this is partly explained by lower sex hormone binding globulin (SHBG) production and hypothalamic-pituitary downregulation, it is still not unravelled whether changes in androgen metabolism contribute to this phenomenon. Therefore, early changes in urinary excretion of T and its metabolites, during weight loss, in men with obesity are investigated. Design Longitudinal study. Methods Fourteen men with obesity (age 52(45–60)years, BMI 42.6(41.8–44.8)kg/m²) underwent gastric bypass surgery (GBS). Before surgery and 3 weeks, 6 weeks, 6 months and 1 year thereafter, 24 h urine and fasting serum samples were collected. Serum T and estradiol (E2) levels were analyzed using LC-MS/MS and urinary metabolites of T with GC-MS/MS. Results Already three weeks after GBS, serum SHBG and total T levels increased and remained increased as compared to baseline (all,p Conclusions Restoration of circulating T levels during weight loss in this population is not only brought about by normalization of circulating SHBG levels, but increased production of and alterations in T metabolism also contribute. More specifically, relative decreases in aromatization and lower 5α-reductase activity might also be involved in restoring T levels in men with obesity. |
| Databáze: | OpenAIRE |
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