Psychosocial Stress Over the Lifespan, Psychological Factors, and Cardiometabolic Risk in the Community

Autor: Mehdi Gholam-Rezaee, Peter Vollenweider, Jennifer Glaus, Sirak Gebreab, Enrique Castelao, Roland von Känel, Pedro Marques-Vidal, Christine Kuehner, Marie-Pierre F. Strippoli, Dominique Rudaz, Aurélie M. Lasserre, Martin Preisig, Caroline L. Vandeleur, Giorgio Pistis
Přispěvatelé: University of Zurich, Gebreab, Sirak Zenebe
Rok vydání: 2018
Předmět:
Adult
Male
Risk
Coping (psychology)
Waist
media_common.quotation_subject
Blood lipids
610 Medicine & health
3202 Applied Psychology
Body Mass Index
Cohort Studies
2738 Psychiatry and Mental Health
03 medical and health sciences
0302 clinical medicine
Metabolic Diseases
Adverse Childhood Experiences
Adaptation
Psychological
Medicine
Personality
Humans
030212 general & internal medicine
Applied Psychology
media_common
Aged
Depressive Disorder
Major
Adaptation
Psychological/physiology
Adverse Childhood Experiences/statistics & numerical data
Cardiovascular Diseases/blood
Cardiovascular Diseases/epidemiology
Cardiovascular Diseases/physiopathology
Depressive Disorder
Major/blood
Depressive Disorder
Major/epidemiology
Depressive Disorder
Major/physiopathology
Female
Metabolic Diseases/blood
Metabolic Diseases/epidemiology
Metabolic Diseases/physiopathology
Middle Aged
Personality/physiology
Stress
Psychological/blood
Stress
Psychological/epidemiology
Stress
Psychological/physiopathology
Switzerland/epidemiology
Waist Circumference/physiology
business.industry
medicine.disease
Obesity
Psychiatry and Mental health
10057 Klinik für Konsiliarpsychiatrie und Psychosomatik
Blood pressure
Cardiovascular Diseases
Waist Circumference
business
Body mass index
030217 neurology & neurosurgery
Stress
Psychological
Switzerland
Clinical psychology
Cohort study
Zdroj: Psychosomatic medicine, vol. 80, no. 7, pp. 628-639
ISSN: 1534-7796
Popis: OBJECTIVE: The complex relationship between psychosocial stress over the lifetime, psychological factors, and cardiometabolic risk is still poorly understood. Accordingly, our aims were (1) to independently assess the associations between childhood adversity, life-event stress in remote (earlier than the last 5 years), and recent adulthood and cardiometabolic risk, and (2) to determine the role of psychological factors including personality, coping, and depression in these associations. METHODS: The sample included 2674 adults, aged 35 to 66 years, randomly selected from urban area. Participants underwent a physical examination including the assessment of obesity markers, blood pressure, and blood lipid and glucose levels. Stress during adulthood was determined using the severity scores of 52 stressful life events. Information on adverse childhood experiences and major depressive disorders was collected using semistructured interviews, whereas personality traits and coping mechanisms were evaluated through questionnaires. RESULTS: Both childhood adversity and stress in remote adulthood were associated with elevated body mass index (β [95% confidence interval {CI}] = 0.249 [0.029 to 0.468]; 0.020 [0.006 to 0.034]), waist circumference (β [95% CI] = 0.061 [0.024 to 0.099]; 0.08 [0.04 to 0.11]), and the global cardiometabolic risk score (β [95% CI] = 0.278 [0.017 to 0.540]; 0.017 [0.001 to 0.033]) after adjustment for sociodemographic, lifestyle, and psychological factors. In addition, childhood adversity was associated with low high density lipoprotein levels (β [95% CI] = -0.021 [-0.042 to 0.000]), as well as increased fat mass and systolic blood pressure levels (β [95% CI] = 0.506 [0.165 to 0.846]; 0.952 [0.165 to 1.740]) and stress in remote adulthood with apolipoprotein B levels (β [95% CI] = 0.607 [0.312 to 0.901]). Psychological factors did not account for these associations and were not effect modifiers. CONCLUSIONS: Our data demonstrate that psychosocial stress during childhood and remote adulthood favor adiposity and abnormal lipid metabolism.
Databáze: OpenAIRE
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