Trimix instead of air, decreases the effect of short-term hyperbaric exposures on platelet and fibrinolysis activation
| Autor: | Piotr Siermontowski, Piotr Radziwon, Joachim F. Schenk, Romuald Olszański, K Van Damme-Ostapowicz, J Łaszczyńska, J Korsak, Alina Lipska, P Gosk, M. Bujno |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Adolescent Nitrogen Decompression Diving medicine.medical_treatment Fibrinogen Helium Trimix Decompression sickness Young Adult Fibrinolysis medicine Humans Platelet Hyperbaric Oxygenation Platelet Count business.industry Air General Medicine Decompression Sickness Platelet Activation medicine.disease Breathing gas Oxygen Anesthesia Breathing business human activities medicine.drug |
| Zdroj: | Advances in Medical Sciences. 55:313-316 |
| ISSN: | 1896-1126 |
| Popis: | Purpose Short-term and saturated simulated dives followed by decompression with air, cause a decrease in platelet count and increased activation of fibrinolysis. The aim of this study was to determine whether short-term dives with trimix as a breathing mixture induce the activation of platelets, and/or fibrinolysis. Material and Methods 30 male divers were subjected to short-term hyperbaric exposures to 0.7 MPa. Thirty divers used air and then the same divers used trimix as a breathing mixture. Results: The mean platelet count dropped significantly after decompression only in the group breathing air. The number of CD62P positive platelets and the amount of platelet-derived micro particles were statistically significant higher after decompression in both exposures. The number of CD61 positive platelets increased significantly only in the group breathing air. We observed a significant decrease of factor XII and fibrinogen concentrations after decompression only in the group breathing air. A significant increase in the concentration of plasmin-antiplasmin complex in both groups was detected. Conclusions Short-term hyperbaric exposure and decompression performed according to current safety standards activates platelets and the fibrinolytic system. Trimix protects divers from a reduction in the amount of platelets, fibrinogen and factor XII in the course of these exposures. |
| Databáze: | OpenAIRE |
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