| Autor: |
Tanda, M. L., Ippolito, S., Gallo, D., Baj, A., Novazzi, F., Genoni, A., Annoni, M., Mancini, N., Clementi, N., Finzi, G., Piantanida, E., Premoli, P., Lai, A., Dalla Gasperina, D., Maggi, F., Uccella, S. |
| Přispěvatelé: |
Tanda, M L, Ippolito, S, Gallo, D, Baj, A, Novazzi, F, Genoni, A, Annoni, M, Mancini, N, Clementi, Nicola, Finzi, G, Piantanida, E, Premoli, P, Lai, A, Dalla Gasperina, D, Maggi, F, Uccella, S |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Endocrinological Investigation |
| Popis: |
Introduction Thyroid dysfunctions associated with SARS-CoV-2 are emerging in scientific literature. During the second COVID-19 epidemic spread, we evaluated a patient with the suspect of subacute thyroiditis. Methods and results Specimen from fine-needle aspiration of a hypoechoic undefined area was analyzed for cytology and for SARS-CoV-2 detection. SARS-CoV-2 was retrieved by real-time polymerase chain reaction on the cytologic sample, which was then cultured on Vero E6 cells and demonstrated to be cytopathic. Whole-genome sequence was deposited. Histological exam diagnosed a rare case of primary thyroid sarcoma with diffuse and strong expression of mouse double minute 2 homolog (MDM2) oncoprotein. Ultrastructural examination confirmed, in several neoplastic cells, the presence of viral particles in cytoplasmic vacuoles. Conclusions In our hypothesis, SARS-CoV-2 and sarcoma coexistence could represent a synergistic interplay, ultimately favoring both viral persistence and tumor proliferation: the overexpression of MDM2 in tumor cells might have generated a favorable immunological niche for SARS-CoV-2 localization and, in turn, SARS-CoV-2 could have favored tumor growth by inducing MDM2-mediated p53 downregulation. Functional studies are needed to confirm this suggestive pathway. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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