Phosphatidylinositol and inositolphosphatide metabolism in hypertrophied rat heart
| Autor: | Hiroshi Okamoto, Toshiyuki Kudo, Hisakazu Yasuda, Norifumi Hirao, Hitoshi Sano, Yoshihito Sakata, Mikako Shoki, Hideaki Kawaguchi, Hirofumi Sawa |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Physiology Stimulation Cardiomegaly Inositol 1 4 5-Trisphosphate Biology Phosphatidylinositols Rats Inbred WKY chemistry.chemical_compound Phosphoinositide Phospholipase C Internal medicine Rats Inbred SHR Phosphoinositide phospholipase C medicine Myocyte Animals Inositol Phosphatidylinositol Phospholipase C Kinase Phosphoric Diester Hydrolases Myocardium Phosphatidylinositol Diacylglycerol-Lyase Inositol Polyphosphate 5-Phosphatases Phosphotransferases Phosphatidylinositol diacylglycerol-lyase Phosphoric Monoester Hydrolases Rats Phosphotransferases (Alcohol Group Acceptor) Endocrinology chemistry Cardiology and Cardiovascular Medicine |
| Zdroj: | Japanese circulation journal. 56(2) |
| ISSN: | 0047-1828 |
| Popis: | The accumulation of both Inositol-(1,4,5)-trisphosphate (IP3) and Inositol-(1,3,4,5)-tetrakisphosphate (IP4) after hormonal stimulation has a physiological role, possibly in altering Ca2+ levels in cardiac tissue. However, the accumulation of inositol polyphosphate under pathophysiological conditions has not been studied. In our experiments the metabolism of phatidylinositol and IP3 in cardiac myocytes as investigated. It was shown that basal levels of cytosolic phosphatidylinositol specific phospholipase C (PI-PLC), phosphatidylinositol-(4,5)-bisphosphate specific phospholipase C (PIP2-PLC) activities markedly increased in stroke-prone spontaneously hypertensive rats (SHRSP) with age compared with age matched Wistar Kyoto rats (WKY). IP3 kinase and IP3 phosphatase activities also increased in SHRSP hearts with age. Their activities increased in WKY, but to a lesser extent than in SHRSPs. These data suggest that a PI turnover pathway such as the phosphatidylinositol 4,5-bisphosphate-IP3-Ca2+ pathway or the diacylglyceride-protein kinase C pathway may have an important role in the development of hypertrophy in SHRSP heart. |
| Databáze: | OpenAIRE |
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