Facile construction of substituted pyrimido[4,5-d]pyrimidones by transformation of enaminouracil
| Autor: | Hana’a A. Al-Saman, Hanafi H. Zoorob, Wafaa S. Hamama, Mohamed A. Ismail |
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| Rok vydání: | 2013 |
| Předmět: |
Ketimine
Indole test chemistry.chemical_classification lcsh:R5-920 Annulation Aldimine Multidisciplinary Chemistry Formaldehyde Uracil Ring (chemistry) Medicinal chemistry chemistry.chemical_compound Molar ratio Organic chemistry Original Article Double Mannich reaction General lcsh:Medicine (General) lcsh:Science (General) Derivative (chemistry) lcsh:Q1-390 |
| Zdroj: | Journal of Advanced Research, Vol 4, Iss 2, Pp 115-121 (2013) Journal of Advanced Research |
| ISSN: | 2090-1232 |
| DOI: | 10.1016/j.jare.2012.01.001 |
| Popis: | The reaction of 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione (1) as a binucleophile with primary aromatic or heterocyclic amines and formaldehyde or aromatic (heterocyclic) aldehydes in a molar ratio (1:1:2) gave the pyrimido[4,5-d]pyrimidin-2,4-dione ring systems 2–5. Treatment of 1 with diamines and formalin in molar ratio (2:1:4) gave the bis-pyrimido[4,5-d]pyrimidin-2,4-diones 6–8. Furthermore, substituted pyrimido[4,5-d]pyrimidin-2,4-diones with uracil derivative 11 or spiro indole 16 were synthesized. Synthesis of pyrimido[4,5-d]pyrimidin-2,4-diones with different substitution at C-5 and C-7 was achieved to give 13 and 18, respectively. |
| Databáze: | OpenAIRE |
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