Endothelin-1 enhances vasoconstrictor responses to sympathetic nerve stimulation and noradrenaline in the rabbit ear artery
| Autor: | M. La, Michael J. Rand, H. K. Wong-Dusting |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic Nervous System Endothelium Physiology Stimulation Blood Pressure In Vitro Techniques Muscle Smooth Vascular Norepinephrine Physiology (medical) Internal medicine medicine Animals Pharmacology business.industry Endothelins Ear Arteries Endothelin 1 Perfusion medicine.anatomical_structure Endocrinology Regional Blood Flow Vasoconstriction Peripheral nervous system Circulatory system cardiovascular system Female Rabbits medicine.symptom business Endothelin receptor medicine.drug |
| Zdroj: | Clinical and experimental pharmacologyphysiology. 18(3) |
| ISSN: | 0305-1870 |
| Popis: | SUMMARY 1. In rabbit isolated perfused ear arteries denuded of endothelium, a low concentration of endothelin-1 (0.1 nmol/L) that had no direct vasoconstrictor action produced slowly developing enhancements of vasoconstrictor responses to noradrenaline and sympathetic nerve stimulation. The enhancements reached maximal levels after 60 min of exposure to endothelin-1. 2. A higher concentration of endothelin-1 (1 nmol/L), which produced a slow-developing increase in perfusion pressure of 70 mmHg over the course of 1 h, significantly enhanced vasoconstrictor responses to sympathetic nerve stimulation for the first 30 min, after which there was no significant enhancement. Responses to noradrenaline were not enhanced by 1 nmol/L endothelin-1. 3. The enhancing effect of low concentrations of endothelin-1 on vasoconstrictor responses to sympathetic nerve stimulation and noradrenaline may play a physiological role in modulating vasomotor function. |
| Databáze: | OpenAIRE |
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