A Novel Approach to Dysmorphology to Enhance the Phenotypic Classification of Autism Spectrum Disorder in the Study to Explore Early Development
| Autor: | Laura A. Schieve, Stuart K. Shapira, Marshalyn Yeargin-Allsopp, Aimee Alexander, Arthur S. Aylsworth, Ellen R. Elias, Anne C.-H. Tsai, Elaine H. Zackai, Naomi Meeks, Margaret C. Souders, Lin H. Tian, Julie Hoover-Fong |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Race ethnicity genetic structures Autism Spectrum Disorder Population Ethnic group behavioral disciplines and activities Article Craniofacial Abnormalities 03 medical and health sciences Child Development 0302 clinical medicine mental disorders Ethnicity Developmental and Educational Psychology medicine Humans 0501 psychology and cognitive sciences Child education education.field_of_study 05 social sciences Facies medicine.disease Phenotype Child development Autism spectrum disorder Child Preschool Autism Female Racial differences Psychology 030217 neurology & neurosurgery 050104 developmental & child psychology Clinical psychology |
| Zdroj: | J Autism Dev Disord |
| ISSN: | 1573-3432 0162-3257 |
| Popis: | The presence of multiple dysmorphic features in some children with autism spectrum disorder (ASD) might identify distinct ASD phenotypes and serve as potential markers for understanding causes and prognoses. To evaluate dysmorphology in ASD, children aged 3–6 years with ASD and non-ASD population controls (POP) from the Study to Explore Early Development were evaluated using a novel, systematic dysmorphology review approach. Separate analyses were conducted for non-Hispanic White, non-Hispanic Black, and Hispanic children. In each racial/ethnic group, ~ 17% of ASD cases were Dysmorphic compared with ~ 5% of POP controls. The ASD–POP differential was not explained by known genetic disorders or birth defects. In future epidemiologic studies, subgrouping ASD cases as Dysmorphic vs. Non-dysmorphic might help delineate risk factors for ASD. |
| Databáze: | OpenAIRE |
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