A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets
| Autor: | Fatma Ahmed Ismail, Ahmed Refaat, Magda Sokar, Nabila A. Boraei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Administration
Oral Pharmaceutical Science 02 engineering and technology orally disintegrating tablets 030226 pharmacology & pharmacy Dosage form chemistry.chemical_compound Freeze-drying Drug Delivery Systems 0302 clinical medicine Drug Stability Hot melt Pharmaceutical industry solid lipid micro pellets Viscosity Fatty Acids General Medicine 021001 nanoscience & nanotechnology Lipids Taste multiparticulate Mannitol HD9665-9675 0210 nano-technology Antipsychotic Agents medicine.drug Drug Liberation medicine.drug_class Drug Compounding Drug Storage Atypical antipsychotic quetapine orally disintegrating tablets Medication Adherence Diglycerides Excipients Quetiapine Fumarate 03 medical and health sciences Hardness medicine Humans Pharmacology Croscarmellose sodium Chromatography quetiapine Freeze Drying chemistry Delayed-Action Preparations Waxes Quetiapine |
| Zdroj: | Acta Pharmaceutica, Vol 66, Iss 4, Pp 515-532 (2016) Acta Pharmaceutica Volume 66 Issue 4 |
| ISSN: | 1846-9558 1330-0075 |
| Popis: | Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique and utilizing three lipid carriers: Compritol, Precirol and white beeswax either alone or in mixtures. They showed sustained QT release and a taste masking effect. The selected QT SLMP was further blended with an aqueous solution containing polyvinylpyrollidone (2.5 %), croscarmellose sodium (2 %) and mannitol (50 %); it was then lyophilized into ODT in a mass ratio of 1:2, respectively. ODTs containing QT SLMPs showed: average wetting time (40.92 s), average oral disintegration time (21.49 s), average hardness (16.85 N) and also imparted suitable viscosity to suspend pellets during the lyophilization process. In conclusion, lyophilization is a promising technique for the formulation of multiparticulate systems into ODTs. |
| Databáze: | OpenAIRE |
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