Physicochemical properties and biological activities of Thai plant mucilages for artificial saliva preparation

Autor:	Witchapong Issarangporn, Narinthorn Khositsuntiwong, Jiradej Manosroi, Kassara Pattamapun, Worapaka Manosroi, Aranya Manosroi, Bang-on Kietthanakorn, Charinya Chankhampan
Rok vydání:	2015
Předmět:	Cell Survival DPPH Pharmaceutical Science Basellaceae Plant Mucilage Artocarpus chemistry.chemical_compound Drug Discovery Botany Humans Cells Cultured Pharmacology biology Traditional medicine Plant Extracts Viscosity Chemistry Saliva Artificial food and beverages General Medicine Fibroblasts Thailand biology.organism_classification Moraceae Basella Complementary and alternative medicine Mucilage Molecular Medicine Lamiaceae Abelmoschus
Zdroj:	Pharmaceutical Biology. 53:1653-1660
ISSN:	1744-5116 1388-0209
Popis:	Plant mucilages can be found in various parts of several Thai plants, which can be used as thickening, moisturizing, and lubricating agents in artificial saliva formulations.The objective of this study was to evaluate the physicochemical properties, biological activity, and cytotoxicity of Thai plant mucilages.The mucilages from Thai plants were extracted by various processes (temperature and pH variation, microwave oven, steam, and Tris-HCl buffer extraction). The viscosity and the rheology were evaluated using viscometer. Antioxidative activities including DPPH radical scavenging and metal chelating activities were investigated. The mucilages were determined for cytotoxicity on normal human gingival fibroblasts and anti-adherent activity of Streptococcus mutans.Mucilages from Ocimum citriodorum Vis. (Lamiaceae), Artocarpus heterophyllus Lam. (Moraceae), Abelmoschus esculentus (Linn.) Moench. (Malvaceae), and Basella alba Linn. (Basellaceae) exhibited pseudoplastic non-Newtonian rheology. The highest DPPH radical-scavenging and metal-chelating activities were observed in the mucilages from B. alba (microwave, 3 min) and A. esculentus (microwave, 1 min) with the SC50 and MC50 values (50% of scavenging activity and 50% of metal chelating activity, respectively) of 0.71 ± 0.32 and 1.11 ± 0.52 mg/ml, respectively. Most mucilages exhibited no cytotoxicity to normal human gingival fibroblasts. The mucilage from A. esculentus (microwave, 5 min) gave the shortest wetting time of 2.75 ± 0.51 min. The highest S. mutans adhesion inhibition was observed in A. esculentus (pH 11) of 5.39 ± 9.70%.This study has indicated the suitable physicochemical and biological properties and the potential application of mucilages from Thai plants for artificial saliva preparation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad861d51a237a2332cc9fc6c48ebd95 https://doi.org/10.3109/13880209.2014.1001402 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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