Blastic plasmacytoid dendritic cell neoplasm: an early presentation
| Autor: | Caroline da Silva Alves Palheta, Cassia Michelle Almeida Fernandes, Caio Vinicius Botelho Brito, Francisca Regina Oliveira Carneiro, Samira Oliveira Silveira, Erica Baptista Pinto, Yandra Sherring Einecke, Leonidas Braga Dias Junior |
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| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Lymphoma Interleukin-3 Receptor alpha Subunit Dermatology Cutaneous lymphoma 030207 dermatology & venereal diseases 03 medical and health sciences Fatal Outcome 0302 clinical medicine Dermis Proto-Oncogene Proteins Precursor cell medicine Atypia Humans blastic plasmacytoid dendritic cell neoplasm cutaneous nodule Acute leukemia business.industry S100 Proteins Nodule (medicine) Dendritic Cells General Medicine Middle Aged medicine.disease medicine.anatomical_structure CD4 Antigens Immunohistochemistry Female Interleukin-3 receptor medicine.symptom business |
| Zdroj: | Silveira, Samira Oliveira; Fernandes, Cassia Michelle Almeida; Pinto, Érica Baptista; Einecke, Yandra Sherring; Palheta, Caroline da Silva Alves; Brito, Caio Vinicius Botelho; et al.(2019). Blastic plasmacytoid dendritic cell neoplasm: an early presentation. Dermatology Online Journal, 25(2). Retrieved from: http://www.escholarship.org/uc/item/9xd132gs |
| ISSN: | 1087-2108 |
| DOI: | 10.5070/d3252042892 |
| Popis: | A blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a cutaneous lymphoma derived from a plasmacytoid dendritic precursor cell that exhibits aggressive clinical behavior. Herein, we report a 46-year-old woman with a complaint of a painless nodule on the back, associated with pruritus. The nodule grew and new growths appeared over six months of evolution. The histopathological examination of one of the left upper limb lesions showed a dense lymphoid cell infiltrate with atypia in the superficial and deep dermis. Immunohistochemistry showed positivity for CD45, S-100 protein, CD123, and TCL 1. About two months after the initial evaluation, the patient was admitted to the Emergency Hospital of Marituba-PA with dyspnea. She progressed to cardiorespiratory arrest and death within 12 hours of admission. There is still no consensus for the treatment of BPDCN. Intensive therapy for acute leukemia can be useful, but allogeneic bone marrow transplantation has a greater chance of long-term survival. |
| Databáze: | OpenAIRE |
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