Effect of High Fructose Corn Sirup on Pancreatic Ductal Adenocarcinoma Induced by Dimethyl Benzantracene (DMBA) in Rats

Autor: Ömer Tarım, Ilker Ercan, Ekrem Kaya, Mustafa Barış Akgül, Senem Suna, Halit Ziya Dündar, Gürsel Sönmez, Turkkan Evrensel, Emre Sarandol, Bige Incedayi, Canan Ece Tamer, Sevda Inan, Deniz Bagdas, Ömer Utku Çopur, Deniz Sigirli, Gulsah Ozcan-Sinir
Přispěvatelé: Bursa Uludağ Üniversitesi/Ziraat Fakültesi/Gıda Mühendisliği Bölümü., Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı., Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı., Bursa Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı., Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı., Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Endokrinolojisi Anabilim Dalı., Sinir-Özcan, Gülşah, Suna, Senem, Tamer, Canan Ece, Sönmez, Gürsel, Evrensel, Türkkan, Kaya, Ekrem, Sarandöl, Emre, Dündar, Halit Ziya, Tarım, Ömer Faruk, Ercan, İlker, Sığırlı, Deniz, İncedayı, Bige, Çopur, Ömer Utku, AAG-8277-2021, ABE-1716-2020, AAQ-8178-2020, AAJ-1027-2021, AAG-7319-2021, AAG-8503-2021, AAG-8336-2021, AAA-7472-2021, ABF-2367-2020
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Sucrose
Cancer Research
Intraepithelial neoplasia
Carcinoma
pancreatic ductal
Rats
sprague-dawley
Carcinogenesis
Glucose blood level
Medicine (miscellaneous)
DMBA
Animal tissue
chemistry.chemical_compound
0302 clinical medicine
Food intake
Glycemic load
Cancer morphology
Nutrition and Dietetics
digestive
oral
and skin physiology
food and beverages
Pancreatic Neoplasms
Pancreas Adenocarcinoma
Chronic Pancreatitis
Nectar
7
12 dimethylbenz[a]anthracene
Sprague dawley rat
Fructose intake
Chow diet
Oncology
030220 oncology & carcinogenesis
Pancreas tumor
Normal dietary consumption
Autopsy
Pancreas adenocarcinoma
medicine.medical_specialty
Pancreatic neoplasms
9
10-Dimethyl-1
2-benzanthracene
Histopathology
Fructose
Tumor differentiation
Body-weight
Zea mays
Pooled analysis
Article
03 medical and health sciences
Internal medicine
Pancreatic cancer
Sham procedure
medicine
Carcinoma
Animals
High fructose corn syrup
Animal model
Clinical evaluation
Obesity
Animal experiment
Sugar
Cancer-risk
Nutrition & dietetics
030109 nutrition & dietetics
Corn syrup
Animal
High-fructose corn syrup
Insulin-resistance
Body weight
Nonhuman
Peach
medicine.disease
Rats
Maize
Glucose
Endocrinology
chemistry
High fructose
Rat
Data analysis software
Comparative study
Pancreas carcinoma
Controlled study
Zdroj: Nutrition and Cancer. 73:339-349
ISSN: 1532-7914
0163-5581
DOI: 10.1080/01635581.2020.1770811
Popis: Increased risk of pancreatic cancer may be associated with consumption of sugar containing foods. The aim of this study was to evaluate the effect of peach nectar containing high fructose corn sirup (HFCS) consumption in a pancreatic carcinogenesis rat model induced by 7,12-Dimethyl benzanthracene (DMBA). Fifty-day-old male Sprague Dawley rats were fed with peach nectar containing HFCS + chow, peach nectar containing sucrose + chow and only chow. After 8 mo, feeding period, each group was divided into two subgroups, in which the rats were implanted with DMBA and no DMBA (sham). Histologic specimens were evaluated according to the routine tissue processing protocol. The animals withad libitumaccess to pn-HFCS, pn-sucrose and chow (only) showed significant differences in chow consumption and glucose level. Necropsy and histopathologic findings showed tumor formation in the entire group treated with DMBA. Excluding one rat in chow group, which was classified as poorly differentiated type, the others were classified as moderately differentiated pancreatic ductal adenocarcinoma (PDAC). This study demonstrated that daily intake of HFCS did not increase body weight and there was no effect of peach nectar consumption on the development of PDAC induced by DMBA in rats.
Databáze: OpenAIRE
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