Congenital transmission of Trypanosoma cruzi: an operational outline for detecting and treating infected infants in northwestern Argentina

Autor: Isolina Flores, Roberto Chuit, Liliana Tulián, Elsa L. Segura, Sonia B. Blanco, Estela N. Cura, Juan F. Villalonga, Ricardo E. Gürtler, Gabriela Garbarino
Jazyk: Spanish; Castilian
Rok vydání: 2000
Předmět:
Pediatrics
Enfermedad de Chagas
Ciencias de la Salud
Serology
Congenital
Tripanosomiasis
Pregnancy
education.field_of_study
biology
Transmission (medicine)
Incidence (epidemiology)
Pruebas Serológicas
Middle Aged
Trypanocidal Agents
Infectious Diseases
Benznidazole
Nitroimidazoles
purl.org/becyt/ford/3 [https]
Female
medicine.drug
Chagas disease
Adult
medicine.medical_specialty
CIENCIAS MÉDICAS Y DE LA SALUD
Population
Argentina
Enzyme-Linked Immunosorbent Assay
purl.org/becyt/ford/3.3 [https]
Trypanosomiasis
Control
parasitic diseases
medicine
Transmission
Epidemiología
Animals
Humans
Chagas Disease
Trypanosoma cruzi
education
Serodiag Nosis
business.industry
Public Health
Environmental and Occupational Health
Infant
Newborn
Infant
Hemagglutination Tests
biology.organism_classification
medicine.disease
Infectious Disease Transmission
Vertical
Pregnancy Complications
Parasitic
Immunology
Parasitology
Nifurtimox
business
Zdroj: Tropical Medicine & International Health, 2000, 5(4), 293–301.
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Popis: We designed a set of procedures for first-line local health services to detect and treat the congenital transmission of Trypanosoma cruzi at a province-wide scale, and field-tested the programme in the province of Tucumam, northwestern Argentina, from 1992 to 1994. The programme consists of routine screening of pregnant women for seroreactivity to T. cruzi, serological and parasitological follow-up of the newborn at least twice during the first year of age, treatment of the infected infants, and evaluation of the outcome. 927 (5.5%) of 16 842 pregnant women were seroreactive to T. cruzi by indirect haemagglutination assay and ELISA. Twenty-one (6.7%) of 315 newborns to seroreactive mothers were diagnosed as infected with T. cruzi parasites microhaematocrit concentration before 30 days of age. Five newborns who initially tested negative had a T. cruzi infection detected by microhaematocrit and/or serological techniques at 3 or 6 months of age. Thus, congenital infection was diagnosed in 26 (7.1%) infants born to seroreactive women and residing in houses free of triatomine bugs. Four of 6 infants born to seroreactive mothers died during the first year of age and had some evidence of T. cruzi infection; one of the deaths was attributed to T. cruzi based on clinical evidence. After specific treatment with nifurtimox or benznidazole, 30 of 32 infants remained parasitologically and serologically negative. This study shows the feasibility of controlling the incidence of congenitally acquired T. cruzi infections at a province-wide scale by means of a specific screening programme at first-line health services level. Fil: Blanco, Sonia B.. Servicio Nacional de Chagas; Argentina Fil: Segura, Elsa Leonor. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina Fil: Cura, Estela N.. Centro de Control de Calidad de Biológicos; Argentina Fil: Chuit, Roberto. Secretaría de Salud de la Nación; Argentina Fil: Tulián, Liliana. Servicio Nacional de Chagas; Argentina Fil: Flores, Isolina. Maternidad de Nuestra Señora de la Merced; Argentina Fil: Garbarino, Gabriela. Maternidad de Nuestra Señora de la Merced; Argentina Fil: Villalonga, Juan F.. Hospital Pediátrico del Niño Jesús; Argentina Fil: Gurtler, Ricardo Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Databáze: OpenAIRE
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