| Autor: |
Guoguang Rong, Yuqiao Zheng, Xiangqing Li, Mengzhun Guo, Yi Su, Sumin Bian, Bobo Dang, Yin Chen, Yanjun Zhang, Linhai Shen, Hui Jin, Renhong Yan, Liaoyong Wen, Peixi Zhu, Mohamad Sawan |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Biosensors and Bioelectronics. 220:114861 |
| ISSN: |
0956-5663 |
| DOI: |
10.1016/j.bios.2022.114861 |
| Popis: |
We propose a label-free biosensor based on a porous silicon resonant microcavity and localized surface plasmon resonance. The biosensor detects SARS-CoV-2 antigen based on engineered trimeric angiotensin converting enzyme-2 binding protein, which is conserved across different variants. Robotic arms run the detection process including sample loading, incubation, sensor surface rinsing, and optical measurements using a portable spectrometer. Both the biosensor and the optical measurement system are readily scalable to accommodate testing a wide range of sample numbers. The limit of detection is 100 TCID |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect