Fourier-Domain Optical Coherence Tomography Imaging in Corneal Epithelial Basement Membrane Dystrophy: A Structural Analysis
| Autor: | Laurent Laroche, Nacim Bouheraoua, Cristina Georgeon, Mohamed El Sanharawi, Taous Hamiche, Vincent Borderie, B Ameline, Isabelle Goemaere, Otman Sandali, Elena Basli |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty genetic structures Confocal Visual Acuity Basement Membrane law.invention Young Adult Optical coherence tomography Confocal microscopy law Cornea medicine Cogan Syndrome Humans Prospective Studies Fourier domain Aged Basement membrane Microscopy Confocal Fourier Analysis medicine.diagnostic_test business.industry Epithelium Corneal Middle Aged medicine.disease eye diseases Epithelium Epithelial basement membrane dystrophy Ophthalmology medicine.anatomical_structure Female sense organs business Tomography Optical Coherence |
| Zdroj: | American Journal of Ophthalmology. 159:755-763.e1 |
| ISSN: | 0002-9394 |
| Popis: | Purpose To investigate the features of corneal epithelial basement membrane dystrophy using spectral-domain optical coherence tomography (SD OCT) and to examine the reliability of SD OCT in distinguishing epithelial basement membrane dystrophy from the normal cornea. Design Diagnostic test study. Methods Forty-five individuals with epithelial basement membrane dystrophy and 45 age- and sex-matched controls with normal corneas were examined, and SD OCT scans of their corneas were performed. In vivo confocal microscopy was performed to confirm or rule out the diagnosis of epithelial basement membrane dystrophy. The structural corneal changes occurring in eyes with epithelial basement membrane dystrophy based on SD OCT findings were described. Results Epithelial abnormalities were observed in 86 of 87 eyes with epithelial basement membrane dystrophy (45 patients) on SD OCT scans. The 2 main features were the presence of an irregular and thickened epithelial basement membrane duplicating or insinuating into the corneal epithelium layer, or both, and the presence of hyperreflective dots. In some cases, we detected hyporeflective spaces between the corneal epithelial layer and the Bowman layer similar to a corneal epithelial detachment. This corneal epithelial detachment sometimes was associated with a cleavage with a stair-step appearance within the corneal epithelial layer. We found a perfect correlation between in vivo confocal microscopy and SD OCT findings in the diagnosis of epithelial basement membrane dystrophy (κ = 0.98). Conclusions SD OCT provides an accurate assessment of the structural changes occurring in eyes with epithelial basement membrane dystrophy. These changes, visible on SD OCT scans, are easily detectable and permit an accurate diagnosis, especially in patients with no biomicroscopically visible corneal changes. |
| Databáze: | OpenAIRE |
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