Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition
| Autor: | Andre Obenaus, Robert M. Yeh, M. G. Finn, Marianne Manchester, Duane E. Prasuhn |
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| Rok vydání: | 2007 |
| Předmět: |
Azides
Stereochemistry viruses Gadolinium Comovirus Alkyne chemistry.chemical_element Contrast Media Crystallography X-Ray Catalysis chemistry.chemical_compound Materials Chemistry DOTA neoplasms chemistry.chemical_classification Gd complexes Metals and Alloys Virion General Chemistry Magnetic Resonance Imaging Cycloaddition Surfaces Coatings and Films Electronic Optical and Magnetic Materials Nucleoprotein Crystallography chemistry Cyclization Alkynes Ceramics and Composites Azide |
| Zdroj: | Chemical communications (Cambridge, England). (12) |
| ISSN: | 1359-7345 |
| Popis: | Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azide-alkyne cycloaddition (CuAAC) and/or with Gd(3+) ions by coordination to the viral nucleoprotein show increased T(1) relaxivity relative to free Gd(DOTA) complexes in solution. |
| Databáze: | OpenAIRE |
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