Current perspectives on repeat hepatic resection for colorectal carcinoma: a review
| Autor: | Quyen D. Chu, Harold J. Wanebo, Michael P. Vezeridis, Konstantine A. Avradopoulos |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Reoperation
medicine.medical_specialty Colorectal cancer business.industry Hepatic resection medicine.medical_treatment Liver Neoplasms Rectum medicine.disease Surgery Metastasis Liver disease medicine.anatomical_structure Adjuvant therapy medicine Carcinoma Hepatectomy Humans Neoplasm Recurrence Local business Colorectal Neoplasms |
| Zdroj: | Surgery. 119(4) |
| ISSN: | 0039-6060 |
| Popis: | Background. Recurrence occurs in 65% to 85% of patients after initial hepatectomy for metastases from colorectal cancer. Approximately one half of these have liver metastases, and in 20% to 30% only the liver is involved. Opportunity for resection is frequently limited because of diffuse liver disease or extrahepatic extension, and only about 10% to 25% of these patients have conditions amenable to resection. This current review is focused on the rationale, indications, and results of reresection of hepatic metastases from colorectal cancer. Methods. The major series of liver resection were reviewed, and the cases of repeat resections were culled out. In addition to standard clinical parameters, the indications and timing after initial resection and the survival and subsequent recurrence after repeat resection were recorded Results. A comprehensive review of the 28 series showed that the mean interval between the first and second liver resections varied from 9 to 33 months and was about 17.5 months in the two largest series. The median survival in series reporting 10 or more patients was 19 months (mean, 24 months), which is comparable to data in single resection series. In the large French Association series containing 1626 patients with single resections and 144 patients with two resections, the 5-year survival was 25% and 16%, respectively. The recurrence rate after repeat resection is high (greater than 60%), and one half are in the liver. The prognostic factors favoring repeat resection are variable, but they include absence of extrahepatic extension of tumor and a complete resection of the liver metastases. Conclusions. Repeat hepatic liver resection for metastatic colorectal cancer in carefully selected patients appears warranted in view of reasonable survival expectations, which approach that of single liver resection. Risk of recurrence is high, however, suggesting the need for rigorous preoperative and intraoperative assessment and postoperative adjuvant therapy. |
| Databáze: | OpenAIRE |
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