Catalyst- and Silane-Controlled Enantioselective Hydrofunctionalization of Alkenes by Cobalt-Catalyzed Hydrogen Atom Transfer and Radical-Polar Crossover

Autor:	Sayori Kanazawa, Kousuke Ebisawa, Eriko Nishi, Hiroki Shigehisa, Hiroaki Kato, Yuka Ooka, Sayura Komatsu, Kana Izumi
Rok vydání:	2020
Předmět:	Chemistry Enantioselective synthesis chemistry.chemical_element General Chemistry Hydrogen atom 010402 general chemistry 01 natural sciences Biochemistry Silane Catalysis 0104 chemical sciences chemistry.chemical_compound Colloid and Surface Chemistry Polymer chemistry Polar Cobalt Chain reaction
Zdroj:	Journal of the American Chemical Society. 142(31)
ISSN:	1520-5126
Popis:	The catalytic enantioselective synthesis of tetrahydrofurans, which are found in the structures of many biologically active natural products, via a transition-metal-catalyzed hydrogen atom transfer (TM-HAT) and radical-polar crossover (RPC) mechanism is described herein. Hydroalkoxylation of nonconjugated alkenes proceeded efficiently with excellent enantioselectivity (up to 94% ee) using a suitable chiral cobalt catalyst
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad1c3e845e459cee36688bd2cab9e99 https://pubmed.ncbi.nlm.nih.gov/32648757 Zobrazit plný text záznamu