Effects of three fentanyl plasma concentrations on the minimum alveolar concentration of isoflurane in Hispaniolan Amazon parrots (Amazona ventralis)
| Autor: | Peter J Pascoe, Michelle G. Hawkins, Heather K Knych, David Sanchez-Migallon Guzman, Philip H. Kass, Tracy L. Drazenovich |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Minimum alveolar concentration Amazona 040301 veterinary sciences Blood Pressure Body Temperature Fentanyl 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Heart Rate 030202 anesthesiology Amazona ventralis Heart rate Animals Medicine Anesthesia Drug Interactions Dose-Response Relationship Drug Isoflurane General Veterinary biology business.industry 04 agricultural and veterinary sciences General Medicine biology.organism_classification Blood pressure Plasma concentration Linear Models Female business medicine.drug |
| Zdroj: | American Journal of Veterinary Research. 79:600-605 |
| ISSN: | 0002-9645 |
| DOI: | 10.2460/ajvr.79.6.600 |
| Popis: | OBJECTIVE To determine effects of 3 plasma concentrations of fentanyl on the minimum alveolar concentration of isoflurane (MACiso) and cardiovascular variables in Hispaniolan Amazon parrots (Amazona ventralis). ANIMALS 6 adult parrots. PROCEDURES In phase 1, anesthesia was induced and maintained with isoflurane; intermittent positive-pressure ventilation was provided. The MACiso was determined for each bird by use of a bracketing method and supramaximal electrical stimulus. Fentanyl (20 μg/kg) was administered IV, and blood samples were collected over time to measure plasma fentanyl concentrations for pharmacokinetic calculations. In phase 2, pharmacokinetic values for individual birds were used for administration of fentanyl to achieve target plasma concentrations of 8, 16, and 32 ng/mL. At each concentration, MACiso and cardiovascular variables were determined. Data were analyzed with mixed-effects multilevel linear regression analysis. RESULTS Mean ± SD fentanyl plasma concentrations were 0 ng/mL, 5.01 ± 1.53 ng/mL, 12.12 ± 3.58 ng/mL, and 24.93 ± 4.13 ng/mL, and MACiso values were 2.09 ± 0.17%, 1.45 ± 0.32%, 1.34 ± 0.31%, and 0.95 ± 0.14% for fentanyl target concentrations of 0, 8, 16, and 32 ng/mL, respectively. Fentanyl significantly decreased MACiso in a dose-dependent manner. Heart rate and blood pressure significantly decreased at all fentanyl doses, compared with values for MACiso at 0 ng of fentanyl/mL. CONCLUSIONS AND CLINICAL RELEVANCE Fentanyl significantly decreased the MACiso in healthy Hispaniolan Amazon parrots, but this was accompanied by a depressive effect on heart rate and blood pressure that would need to be considered for application of this technique in clinical settings. |
| Databáze: | OpenAIRE |
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