Single-dose intravenous valproate in acute mania
| Autor: | Julia Applebaum, Hanoch Miodovnick, Katrina Phrolov, Robert H. Belmaker, Joseph Levine |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Bipolar Disorder medicine.drug_class medicine.medical_treatment Acute mania Status epilepticus Young Mania Rating Scale Antimanic Agents medicine Humans Young adult Infusions Intravenous Chemotherapy Dose-Response Relationship Drug business.industry Valproic Acid Mood stabilizer Middle Aged Psychiatry and Mental health Treatment Outcome Anesthesia Toxicity Acute Disease Female medicine.symptom business Mania |
| Zdroj: | The Journal of clinical psychiatry. 65(1) |
| ISSN: | 0160-6689 |
| Popis: | Objective: High-dose loading with oral and intravenous valproate has been reported to be therapeutic in mania over 48 to 72 hours. We hypothesized that very high dose intravenous (IV) valproate might have even more rapid effects equivalent to effects in status epilepticus that occur within 20 minutes. Method: Seven patients with mania (Young Mania Rating Scale score > 20) and minimal prior drug treatment were given valproate 20 mg/kg IV over 30 minutes. Results: No antimanic effects were observed during 120 minutes of observation. There were no side effects. Conclusion: Slowly evolving biochemical changes, perhaps at the gene level, may be required for the antimanic effect of anticonvulsants. |
| Databáze: | OpenAIRE |
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