Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort study
| Autor: | Fernanda Luisa Ceragioli Oliveira, Cecília Zanin Palchetti, Daisy Maria Machado, Regina Célia de Menezes Succi, Patrícia Fonseca Teixeira, Rose Vega Patin, Vera Lúcia Szejnfeld |
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| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty lcsh:QR1-502 HIV Infections Body composition lcsh:Microbiology lcsh:Infectious and parasitic diseases Absorptiometry Photon Bone Density Internal medicine Bayesian multivariate linear regression Hiv infected Bone mineral density Medicine Humans lcsh:RC109-216 Prospective Studies Child Bone mineral Medicine(all) business.industry Puberty HIV Anthropometry Infectious Diseases Endocrinology Dietary Reference Intake Lean body mass Body Composition Bone mineral content Female business Cohort study |
| Zdroj: | Brazilian Journal of Infectious Diseases v.19 n.6 2015 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Volume: 19, Issue: 6, Pages: 623-630, Published: DEC 2015 Brazilian Journal of Infectious Diseases, Vol 19, Iss 6, Pp 623-630 (2015) |
| ISSN: | 1678-4391 |
| Popis: | Objective: To evaluate bone mass accrual and determine the influence of clinical, anthropometric, dietary and biochemical parameters on bone mass. Methods: A cohort study including 35 prepubertal HIV-infected children, between 7 and 12 years, attended at a referral center. At time 1 (T1) and time 2 (T2), patients were assessed according to clinical, anthropometric, dietary, biochemical parameters and bone mineral density (BMD). At T2, patients were divided into prepubertal and pubertal. Results: Despite the increase in bone mass absolute values, there was no improvement in lumbar spine BMD (LSBMD) Z-score (p = 0.512) and worsening in total body BMD (TBMD) Z-score (p = 0.040). Pubertal patients (n = 19) showed higher bone mineral content (BMC) (p = 0.001), TBMD (p = 0.006) and LSBMD (p = 0.002) compared to prepubertal patients. After multivariate linear regression analysis, the predictors of bone mass in T1 were age, BMI and HA Z-scores for BMC; BMI Z-score, adequate serum magnesium concentration and dietary calcium intake for TBMD; adequate serum concentration of magnesium, BMI and HA Z-scores for LSBMD. In T2, age, total body fat and lean body mass (kg) for BMC; BMI Z-score and puberty for TBMD; dietary fat intake, BMI Z-score for BMD and puberty for LSBMD. Conclusion: HIV-infected children have compromised bone mass and the presence of puberty seems to provide suitability of these parameters. Adequate intake of calcium and fat appears to be protective for proper bone mass accumulation factor, as well as monitoring nutritional status and serum magnesium concentration. Keywords: HIV, Child, Body composition, Bone mineral density |
| Databáze: | OpenAIRE |
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