Tiagabine: Absence of Kinetic or Dynamic Interactions with Ethanol
| Autor: | Keith Wesnes, Cole G, Jansen Ja, Kastberg H |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Psychometrics Tiagabine media_common.quotation_subject Nipecotic Acids Cmax Pharmacology Placebo Cognition Double-Blind Method Pharmacokinetics medicine Humans Drug Interactions Neurotransmitter Uptake Inhibitors Pharmacology (medical) Diagnosis Computer-Assisted Adverse effect media_common Cross-Over Studies Ethanol business.industry Alertness Pharmacodynamics Anticonvulsants Female business medicine.drug Vigilance (psychology) |
| Zdroj: | Drug Metabolism and Drug Interactions. 14 |
| ISSN: | 2191-0162 0792-5077 |
| DOI: | 10.1515/dmdi.1998.14.4.259 |
| Popis: | Tiagabine is a new antiepileptic drug that inhibits the uptake of gamma-aminobutyric acid into neurons and glia. This double-blind, placebo-controlled study investigated the effect of multiple doses of tiagabine on the adverse cognitive effects produced by a single dose of ethanol in 20 healthy volunteers. The effects of each drug on the pharmaco-kinetics of the other were also determined. Compared with placebo, tiagabine produced no statistically significant effects on digit vigilance speed (primary assessment variable) or accuracy, choice reaction time, immediate or delayed word recall, delayed word recognition speed or sensitivity, visual tracking, body sway, or subjective measures of alertness, calmness, and contentment. There was no evidence of a pharmacodynamic interaction between tiagabine and ethanol with respect to these variables. The pharmacokinetic parameters of tiagabine and ethanol (maximum plasma concentration [Cmax], time to Cmax and area under the plasma concentration-time curve) were unchanged during concomitant administration. Adverse events, which mainly affected the central nervous system, occurred with a similar incidence during tiagabine and placebo administration and were more common after the administration of ethanol. There appears to be no need for additional caution regarding driving or operating machinery when ethanol is administered to patients taking tiagabine. |
| Databáze: | OpenAIRE |
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