Blood-brain barrier disruption and neuroinflammation as pathophysiological mechanisms of the diffuse manifestations of neuropsychiatric systemic lupus erythematosus
| Autor: | Nancy P. Duarte-Delgado, Gloria Vásquez, Blanca Ortiz-Reyes |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Psychosis Cell Membrane Permeability Neuroimmunomodulation Immunology 03 medical and health sciences 0302 clinical medicine immune system diseases medicine Humans Lupus Erythematosus Systemic Immunology and Allergy Lupus vasculitis skin and connective tissue diseases Pathological Neuroinflammation 030203 arthritis & rheumatology Autoimmune disease Lupus erythematosus business.industry Lupus Vasculitis Central Nervous System Autoantibody medicine.disease Pathophysiology 030104 developmental biology Blood-Brain Barrier Encephalitis business |
| Zdroj: | Autoimmunity Reviews. 18:426-432 |
| ISSN: | 1568-9972 |
| DOI: | 10.1016/j.autrev.2018.12.004 |
| Popis: | Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that can involve nervous system commitment known as neuropsychiatric systemic lupus erythematosus (NPSLE). The diagnostic of NPSLE is complex because the symptoms range from focal symptoms (e.g., strokes, thrombotic events) to diffuse disorders affecting cognition, mood and level of consciousness (e.g. acute confusional state, psychosis). Both type of manifestations of NPSLE differ in their pathological mechanisms. The focus of this review will be on the mechanisms that lead to the blood-brain barrier (BBB) disruption and to the neuroinflammation related with the diffuse manifestations of NPSLE. |
| Databáze: | OpenAIRE |
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