Evaluation of the bioaccessibility of a carotenoid beadlet blend using an in vitro system mimicking the upper gastrointestinal tract
| Autor: | Katja Lange, Kevin W. Gellenbeck, Susann Bellmann, Chun Hu, Annet J. H. Maathuis, Dawna Venzon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Lutein 030109 nutrition & dietetics 030102 biochemistry & molecular biology TIM‐1 Nutrition. Foods and food supply gut simulation Lycopene bioaccessibility carotenoid Bioavailability Zeaxanthin 03 medical and health sciences chemistry.chemical_compound chemistry In vitro system Upper gastrointestinal TX341-641 Food science Digestion Carotenoid Food Science Original Research |
| Zdroj: | Food Science & Nutrition, Vol 9, Iss 6, Pp 3289-3296 (2021) Food Science & Nutrition |
| ISSN: | 2048-7177 |
| Popis: | The release characteristics of a unique blend of carotenoid beadlets designed to increase bioavailability were tested using the dynamic gastrointestinal model TIM‐1. Individual carotenoid bioaccessibility peaks were observed over approximately 3–4 hr in the order of lutein and zeaxanthin first, followed by lycopene, and then finally α‐ and β‐carotene; when tested as a beadlet blend or when the beadlets were compressed into tablets. Bioaccessibility measurements of 7%–20% were similar to those previously reported in literature and comparable between the two formulations, beadlet blend and tablet formulations. Total recovery of carotenoids from all compartments ranged from 70% to 90% for all carotenoids, except lycopene where almost 50% was unrecoverable after digestion in the TIM system. The release characteristics of a unique blend of carotenoid beadlets designed for increased bioavailability were tested using the dynamic gastrointestinal model TIM‐1. Peak bioaccessibility measurements separated over approximately 3–4 hr in the order of lutein and zeaxanthin first, followed by lycopene, and then finally alpha and beta carotene; both when tested as a beadlet blend alone and when tested as compressed tablets. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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