A NovelN6-Substituted Adenosine Isolated from Mi Huan Jun (Armillaria mellea) as a Cerebral-Protecting Compound
| Autor: | Masaharu Tamai, Xiao-Tian Liang, J H Huan, Naoharu Watanabe, De-Quan Yu, J S Yang, T Obuchi, Sadafumi Omura, H. Araki |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Adenosine Ratón Pharmaceutical Science Analytical Chemistry Mice Chinese traditional Drug Discovery Botany medicine Animals Medicine Chinese Traditional Purine metabolism Mycelium Pharmacology Mice Inbred ICR Molecular Structure biology Spectrum Analysis Organic Chemistry Brain Armillaria mellea biology.organism_classification Molecular biology Complementary and alternative medicine Molecular Medicine Spectrum analysis Agaricales medicine.drug |
| Zdroj: | Planta Medica. 56:48-52 |
| ISSN: | 1439-0221 0032-0943 |
| Popis: | Successive purification of a crude extract of cultured Mi Huan Jun mycelia, followed by an assay of the effect on complete ischemia in mice, led to the isolation of a new compound with cerebral protecting activity, hereafter designated as AMG-1. The structure of AMG-1 was proposed as being 6-(5-hydroxy-2-pyridyl-methylamino)-9-beta-ribofuranosylpurine (1) on the basis of its UV, mass, 1H-NMR, and 13C-NMR spectra. |
| Databáze: | OpenAIRE |
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