PI3K Inhibitors and Their Role as Novel Agents for Targeted Therapy in Lymphoma
| Autor: | Sarit Assouline, Sasha Sapon-Cousineau, Vladimir Sapon-Cousineau |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Lymphoma medicine.medical_treatment Phosphoinositide 3-kinase inhibitor Antineoplastic Agents Targeted therapy 03 medical and health sciences chemistry.chemical_compound Phosphatidylinositol 3-Kinases 0302 clinical medicine Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Pharmacology (medical) Molecular Targeted Therapy Adverse effect PI3K/AKT/mTOR pathway Copanlisib Phosphoinositide-3 Kinase Inhibitors Clinical Trials as Topic business.industry Disease Management medicine.disease Duvelisib 030104 developmental biology Treatment Outcome chemistry 030220 oncology & carcinogenesis Idelalisib business Signal Transduction |
| Zdroj: | Current treatment options in oncology. 21(6) |
| ISSN: | 1534-6277 |
| Popis: | Phosphatidylinositol 3-kinase (PI3K) inhibitors represent a novel class of agents targeting the key cellular regulatory PI3K/AKT/mTOR pathway involved in crucial functions such as cellular proliferation, cell cycle regulation, protein synthesis, and cell motility. This review starts with an overview of the PI3K pathway and the rationale for its targeting in lymphoma and potential on-target side effects of PI3K inhibition. With three agents now FDA approved for the treatment of relapsed and refractory (R/R) indolent non-Hodgkin lymphoma (iNHL), idelalisib, copanlisib, and duvelisib, we aim to review the pivotal trials leading to their approval as well as their clinical applications according to lymphoma subtypes. Important treatment-related adverse events are also reviewed and a perspective on the clinical role of these agents is provided, as well as some practical guidance on how to prevent, monitor, and manage potential adverse events in the clinic. PI3K inhibitors have an established role in the management of R/R iNHL, but their use and development are hampered by adverse events, particularly when used in combination with other anti-lymphoma therapies. Finally, this review highlights areas in need of more research in order to optimally use these agents in the care of patients with lymphoma. |
| Databáze: | OpenAIRE |
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