Kallikrein and amylase contents in tissues from a mutant mouse model for human cystic fibrosis
| Autor: | A. Martinez Seeber, M.I. Vaccaro, S. B. Vila, Omar H. Pivetta, O. L. Catanzaro |
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| Rok vydání: | 1983 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Cystic Fibrosis Genotype Submandibular Gland Mutant Cystic fibrosis General Biochemistry Genetics and Molecular Biology Mice Animal model Internal medicine medicine Animals Humans Tissue Distribution Amylase General Pharmacology Toxicology and Pharmaceutics Pancreas Kidney biology urogenital system Homozygote DNA General Medicine Kallikrein medicine.disease Disease Models Animal medicine.anatomical_structure Endocrinology Mice Inbred DBA Amylases Mutation biology.protein Nucleic acid RNA Female Kallikreins circulatory and respiratory physiology |
| Zdroj: | Life Sciences. 32:825-831 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(83)90218-7 |
| Popis: | Kallikrein and amylase activities are decreased in the pancreas and salivary glands from cri/cri homozygote mutant mice. Kallikrein is decreased in the cri/cri kidney too. With reference to nucleic acid concentrations there is no difference between control and mutant mice. The previously described electrolyte abnormalities of the cribriform degeneration (cri) mutant mouse, could be due to the abnormal activity of the kallikrein-kinin system on the transport mechanism of tubular cells in the organs mentioned. These findings represent a new step on our efforts to develop a useful animal model for human cystic fibrosis research. |
| Databáze: | OpenAIRE |
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