Global Allergy Forum and 3rd Davos Declaration 2015: Atopic dermatitis/Eczema: challenges and opportunities toward precision medicine

Autor: M. Augustin, Uwe Gieler, M. Mohrenschlager, Hans-Uwe Simon, D. Munch, Wolfram Hoetzenecker, Lisa A. Beck, D. Straub, Jens-Michael Schröder, M. Sokolowska, Alan D. Irvine, Thomas Bieber, H. Koren, K. Grando, K. Schiesser, R. Frei, Liam O'Mahony, L. Eichenfeld, Natalija Novak, Christian Vestergaard, Claudia Traidl-Hoffmann, Martin Glatz, J. Gutermuth, Ph.I. Spuls, J.-P. Allam, Thomas Clavel, DirkJan Hijnen, Roberto Takaoka, Christian Apfelbacher, Kilian Eyerich, Tilo Biedermann, Norito Katoh, Peter Schmid-Grendelmeier, Jack Green, A. Wollenberg, Amy S. Paller, M. Deleuran, Stefanie Gilles, R. Lauener, HW Duchna, J. Ring, C. Rhyner, A. Todorova, Emma Guttman-Yassky, Zsuzsanna Szalai, Daniela Dittlein, Gail Todd, Fook Tim Chew, Thomas Werfel, Cezmi A. Akdis, Dagmar Simon, Georg Schäppi, Charlotte Braun-Fahrländer, Ulf Darsow, A. Kalweit, Jean-François Stalder, Edward F. Knol, Caroline Roduit, R. Crameri, Alain Taieb, Carlo Gelmetti, Jon M. Hanifin
Přispěvatelé: AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Dermatology, Skin function and permeability, Surgical clinical sciences
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Allergy, 71(5), 588-592. Wiley-Blackwell
Allergy
Bieber, T, Akdis, C, Lauener, R, Traidl-Hoffmann, C, Schmid-Grendelmeier, P, Schäppi, G, Allam, J-P, Apfelbacher, C, Augustin, M, Beck, L, Biedermann, T, Braun-Fahrländer, C, Chew, F T, Clavel, T, Crameri, R, Darsow, U, Deleuran, M, Dittlein, D, Duchna, H-W, Eichenfeld, L, Eyerich, K, Frei, R, Gelmetti, C, Gieler, U, Gilles, S, Glatz, M, Grando, K, Green, J, Gutermuth, J, Guttman-Yassky, E, Hanifin, J, Hijnen, D, Hoetzenecker, W, Irvine, A, Kalweit, A, Katoh, N, Knol, E, Koren, H, Möhrenschlager, M, Münch, D, Novak, N, O'Mahony, L, Paller, A S, Rhyner, C, Roduit, C, Schiesser, K, Schröder, J, Simon, D, Simon, H-U, Sokolowska, M, Spuls, P, Stalder, J-F, Straub, D, Szalai, Z, Taieb, A, Takaoka, R, Todd, G, Todorova, A, Vestergaard, C, Werfel, T, Wollenberg, A & Ring, J 2016, ' Global Allergy Forum and 3rd Davos Declaration 2015 : Atopic dermatitis/Eczema: challenges and opportunities toward precision medicine ', Allergy: European Journal of Allergy and Clinical Immunology, Supplement, vol. 71, no. 5, pp. 588-92 . https://doi.org/10.1111/all.12857
ISSN: 0105-4538
DOI: 10.1111/all.12857
Popis: Atopic dermatitis/eczema (AD) is a highly complex disease showing a clear increase in its incidence across all continents during the last decades 1, 2. It is the most common skin disease and has, almost other allergic diseases, a substantial socioeconomic impact 3. The complexity of the underlying mechanisms explains the wide spectrum of the clinical phenotype such as the age of onset, natural history, range of sensitization, provocation factors, clinical appearance, severity, and therapeutic response. Moreover, progress in the last years 4 has also highlighted the potential role of the skin microbiome, neuro‐immunological signals, and epigenetic regulation in the modulation of the disease, adding another level of complexity. This situation calls for a more differentiated approach in our efforts to understand the pathophysiology and to develop new preventative and therapeutic strategies better tailored for the subsets of this complex phenotype. This is particularly true when we consider the infantile and childhood onsets of AD, which are currently regarded as the first step of the feared atopic march including allergic rhinitis and/or asthma 5, 6. Thus, AD should more be considered as a systemic disease with a number of relevant comorbidities 7, 8, which will greatly benefit from new developments in the era of precision medicine 9. In July 2015, a group of 63 scientists and clinicians from 13 countries gathered under the auspices of the Christine Kuhne – Center for Allergy Research and Education (CK‐CARE) for the 3rd Global Allergy Forum in Davos, Switzerland. As in the past, the scientists intensely discussed key issues relevant in the field of allergy and AD 10, 11. The aim of the Think Tank meeting in 2015 was to define and discuss new strategies in research and education in AD, which will pave the way for the precision medicine pathways in AD. This document is not meant to be a comprehensive list of research areas but rather summarizes the main results of the working groups in charge of the six most important fields considered for this meeting.
Databáze: OpenAIRE
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