Analysis of genetic alterations in salivary gland tumors by comparative genomic hybridization
| Autor: | Hideki Fujitsuka, Makoto Toida, Tomohiro Mori, Jun Ichi Ishimaru, Hideki Ichihara, Kyoko Yokoyama, Róza Ádány, Margit Balázs, Iwao Hyodo, Norichika Tatematsu |
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| Rok vydání: | 2001 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities Cancer Research Adenoid cystic carcinoma Karyometry Basal cell adenocarcinoma Adenoma Pleomorphic Biology Genome Translocation Genetic Image Processing Computer-Assisted Genetics medicine Chromosomes Human Humans Molecular Biology In Situ Hybridization Fluorescence Aged Chromosome Aberrations Salivary gland Orvostudományok DNA Neoplasm Middle Aged Salivary Gland Neoplasms medicine.disease Carcinoma Adenoid Cystic Chromosome Banding Molecular hybridization stomatognathic diseases medicine.anatomical_structure Carcinoma Basal Cell Cancer research Female Egészségtudományok Comparative genomic hybridization |
| Zdroj: | Cancer Genetics and Cytogenetics. 127:34-37 |
| ISSN: | 0165-4608 |
| Popis: | In order to define and map chromosomal copy number alterations in salivary gland tumors (SGTs), a comparative genomic hybridization (CGH) technique was applied to two pleomorphic adenomas (PAs), one adenoid cystic carcinoma (ACC), and one basal cell adenocarcinoma (BCAC). The PAs exhibited regional copy number losses at 5q12.4-q14.1, 9q12-q21.13, and 16q11.2, as well as a gain at 20p12.1; among these, the losses at the 9q12-q21.11 and 16q11.2 regions were common to both PAs. The ACC showed overrepresentations of the entire regions of chromosomes 16 and 20, a regional gain at 22q12.3-q13.1, and no losses. In the BCAC, regional gains at 9p21.1-pter, 18q21.1-q22.3, and 22q11.23-q13.31 as well as losses at 2q24.2 and 4q25-q27 were seen; the gain at 22q12.3-q13.1 was common in both the ACC and the BCAC. These CGH data indicate that different genetic alterations are present in the different types of SGTs, and that the alterations involve several chromosomes. The discovery of common alterations in the same and/or different types of tumors might be important in the understanding of the development and progression of the SGTs. |
| Databáze: | OpenAIRE |
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