Determination of drug-induced changes in functional MRI signal using a pharmacokinetic model
| Autor: | Raymond G. Hoffmann, John Pankiewicz, Alan S. Bloom, Elliot A. Stein, Harold H. Harsch, Scott A. Fuller |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Nicotine Models Neurological computer.software_genre Text mining Pharmacokinetics Voxel Image Processing Computer-Assisted medicine Humans Computer Simulation Radiology Nuclear Medicine and imaging Research Articles Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Brain Magnetic resonance imaging Magnetic Resonance Imaging Grouped data Neurology Data extraction Injections Intravenous Neurology (clinical) Onset of action Anatomy Functional magnetic resonance imaging business Psychology computer Neuroscience Algorithms |
| Zdroj: | Hum Brain Mapp |
| ISSN: | 1097-0193 1065-9471 |
| DOI: | 10.1002/(sici)1097-0193(1999)8:4<235::aid-hbm7>3.0.co;2-3 |
| Popis: | As the applications of functional magnetic resonance imaging (fMRI) expand, there is a need for the development of new strategies for data extraction and analysis that do not require the presentation of stimuli in a repeated on/off pattern. A description and evaluation of a method and computer algorithm for the detection and analysis of brain activation patterns following acute drug administration using fMRI are presented. A waveform analysis protocol (WAP) input function has been developed that is based upon the single‐dose pharmacokinetics of a drug of interest. As a result of this analysis, regional brain activation can be characterized by its localization and intensity of activation, onset of action, time to peak effect, and duration of action. A global statistical test for significant drug effects based upon the probability of a voxel being activated by a saline vehicle injection is applied to grouped data on a voxel by voxel basis. Representative data are presented using nicotine as a prototypical agent. Using this method, statistically significant drug‐induced brain activation has been identified in several key cortical and subcortical brain regions. Hum Brain Mapping 8:235–244, 1999. © 1999 Wiley‐Liss, Inc. |
| Databáze: | OpenAIRE |
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