Protective and Pathogenic Effects of Interferon Signaling During Pregnancy
| Autor: | Jonathan J. Miner, Rebecca L. Casazza, Helen M. Lazear |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Primates
0301 basic medicine Placenta Immunology Reviews Context (language use) Antiviral Agents Autoimmune Diseases Zika virus Mice 03 medical and health sciences 0302 clinical medicine Pregnancy Interferon Virology medicine Animals Humans Pregnancy Complications Infectious Autoimmune disease Fetus biology Zika Virus Infection business.industry Pregnancy Outcome medicine.disease biology.organism_classification Immunity Innate Disease Models Animal Congenital infections 030104 developmental biology medicine.anatomical_structure Molecular Medicine Female 030211 gastroenterology & hepatology Interferons business Signal Transduction medicine.drug |
| Zdroj: | Viral Immunol |
| ISSN: | 1557-8976 0882-8245 |
| Popis: | Immune regulation at the maternal-fetal interface is complex due to conflicting immunological objectives: protection of the fetus from maternal pathogens and prevention of immune-mediated rejection of the semiallogeneic fetus and placenta. Interferon (IFN) signaling plays an important role in restricting congenital infections as well as in the physiology of healthy pregnancies. In this review, we discuss the antiviral and pathogenic effects of type I IFN (IFN-α, IFN-β), type II IFN (IFN-γ), and type III IFN (IFN-λ) during pregnancy, with an emphasis on mouse and non-human primate models of congenital Zika virus infection. In the context of these animal model systems, we examine the role of IFN signaling during healthy pregnancy. Finally, we review mechanisms by which dysregulated type I IFN responses contribute to poor pregnancy outcomes in humans with autoimmune disease, including interferonopathies and systemic lupus erythematosus. |
| Databáze: | OpenAIRE |
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