Effects of curcumin on methyl methanesulfonate damage to mouse kidney
| Autor: | Senad Kalkan, Seda Çetinkaya, İbrahim Hakkı Ciğerci, Gokhan Cuce, Mehmet Enes Sözen, Serkan Küççüktürk, N Isitez, Hasan Hüseyin Demirel |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Curcumin Histology medicine.medical_treatment Vacuole Pharmacology Kidney Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Saline TUNEL assay Chemistry organic chemicals fungi Acute kidney injury DNA General Medicine Acute Kidney Injury Methyl Methanesulfonate medicine.disease Methyl methanesulfonate Medical Laboratory Technology 030104 developmental biology medicine.anatomical_structure Biochemistry Apoptosis 030220 oncology & carcinogenesis |
| Zdroj: | Biotechnic & Histochemistry. 91:122-127 |
| ISSN: | 1473-7760 1052-0295 |
| Popis: | Methylmethane sulfonate (MMS) is an alkylating agent that may react with DNA and damage it. We investigated histological changes and apoptosis caused by MMS and the effects of curcumin on MMS treated mouse kidneys. Twenty-four mice were divided into four equal groups: controls injected with saline, a group injected with 40 mg/kg MMS, a group injected with 40 mg/kg MMS and given 100 mg/kg curcumin by gavage, and a group given 100 mg/kg curcumin by gavage. MMS caused congestion and vacuole formation, and elevated the apoptotic index significantly, but had no other effect on kidney tissue. Curcumin improved the congestion and vacuole formation caused by MMS and decreased the apoptotic index. Curcumin administered with MMS appears to decrease the deleterious effects of MMS on the kidney. |
| Databáze: | OpenAIRE |
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