Acute Intoxications Involving α-Pyrrolidinobutiophenone (α-PBP): Results from the Swedish STRIDA Project

Autor: Anders Helander, Olof Beck, Matilda Bäckberg, Lisa Franzen
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Pyrrolidines
Health
Toxicology and Mutagenesis
Urine
Anxiety
Toxicology
01 natural sciences
Mass Spectrometry
law.invention
Designer Drugs
Drug Users
chemistry.chemical_compound
0302 clinical medicine
law
Pentanones
Tachycardia
Chromatography
High Pressure Liquid
Psychomotor Agitation
Medical record
Middle Aged
Intensive care unit
Hypertension
Original Article
Female
medicine.symptom
Poisons information
medicine.drug
Adult
medicine.medical_specialty
Cathinone
Pyrovalerone
Drug overdose
NPS
03 medical and health sciences
α-PBP
Young Adult
Internal medicine
medicine
Humans
Demography
Retrospective Studies
Sweden
business.industry
010401 analytical chemistry
Central Nervous System Depressants
medicine.disease
0104 chemical sciences
chemistry
New psychoactive substances
Drug Overdose
business
Intoxications
030217 neurology & neurosurgery
Zdroj: Journal of Medical Toxicology
ISSN: 1937-6995
1556-9039
Popis: Introduction Many new psychoactive substances (NPS) introduced as recreational drugs have been associated with severe intoxication and death. Methods Blood and/or urine samples were collected from intoxicated patients treated at Swedish hospitals that participated in the STRIDA project, a nationawide effort to address the growing problem of NPS. In patients undergoing evaluation for drug overdose, α-PBP was identified using liquid chromatography-mass spectrometry. Demographic and clinical data were collected during Poisons Information Centre consultations and retrieved from medical records. Results From April 2013 to November 2015, 43 patients tested positive for α-PBP. However, α-PBP was never specifically mentioned during consultation but only confirmed analytically. The α-PBP concentrations ranged 2.0–13,200 ng/mL in urine and 2.0–440 ng/mL in serum. The patients were aged 19–57 (mean 34) years, 81% were men, and 73% were known drug addicts. All cases except 1 also involved other NPS and/or classical drugs. MDPV, α-PVP, and other pyrovalerone analogues were the most common other NPS (31 cases; 72%). CNS depressants were detected in 28 cases (65%), with benzodiazepines (16 cases) being most frequent. Main clinical characteristics were agitation/anxiety (59%), tachycardia (54%), and hypertension (37%), and 14 patients (33%) required monitoring in the intensive care unit of which 8 were graded as severe intoxications. No fatalities were reported. Conclusion Patients with intoxication from α-PBP resembled those by NPS cathinones MDPV and α-PVP. As patients never specifically declared α-PBP intake and poly-drug intoxication was common, they may have been unaware of the actual substance taken.
Databáze: OpenAIRE
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