Annomontine, an Alkaloid Isolated fromAnnona purpurea, Has Anxiolytic-Like Effects in the Elevated Plus-Maze
| Autor: | Diego Cortes, Gabriel Roldán, Miguel Pérez de la Mora, Alma Rosa González-Esquinca, José del Carmen Rejón-Orantes |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Flumazenil
Male Elevated plus maze medicine.drug_class medicine.medical_treatment Intraperitoneal injection Pharmaceutical Science Anxiety Motor Activity Pharmacology Plant Roots Anxiolytic Annona Open field Analytical Chemistry Benzodiazepines Mice Drug Discovery medicine Animals Maze Learning GABA Agonists Mice Inbred BALB C Binding Sites Behavior Animal Dose-Response Relationship Drug biology Plant Extracts Organic Chemistry Antagonist biology.organism_classification Motor coordination Annona purpurea Pyrimidines Anti-Anxiety Agents Complementary and alternative medicine Molecular Medicine Hypnosis Carbolines Phytotherapy medicine.drug |
| Zdroj: | Planta Medica. 77:322-327 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-0030-1250406 |
| Popis: | The effects of annomontine, a pyrimidine- β-carboline alkaloid isolated from the root of ANNONA PURPUREA, on anxiety was studied in mice using the elevated plus-maze. The behavioral effects of this alkaloid on the pentobarbital-induced hypnosis, the locomotor activity in an open field, and the motor coordination in the rotarod test were also evaluated. The intraperitoneal injection of annomontine (1-30 mg/kg) increased in a dose-dependent way the number of visits to and the time spent in the open arms of the elevated plus-maze in comparison to the control animals. Such effects were blocked by the prior application of flumazenil (3 mg/kg; i. p.), a specific antagonist for the binding of benzodiazepines on the GABA (A) receptor. Under the same experimental conditions annomontine failed to affect the behavior of the animals in the pentobarbital-induced hypnosis test and had no effects on locomotion and motor coordination. These results suggest that annomontine possesses anxiolytic-like effects which may be mediated at the level of the benzodiazepine binding site on the GABA (A) receptor. |
| Databáze: | OpenAIRE |
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