Different Accumulation Profiles of Multiple Components Between Pericarp and Seed of Alpinia oxyphylla Capsular Fruit as Determined by UFLC-MS/MS
| Autor: | Yong Hui Li, Feng Chen, Hai Long Li, Yin Feng Tan, Jun Qing Zhang, Wei Wei Guan, Yuan Sheng Zhao, Zhen Miao Qin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
China
secondary metabolites A. oxyphylla capsular fruits diarylheptanoids flavonoids nootkatone production region UFLC-MS/MS Climate Pharmaceutical Science Tandem mass spectrometry High-performance liquid chromatography Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Tandem Mass Spectrometry Drug Discovery Nootkatone Botany Chrysin Physical and Theoretical Chemistry Alpinia oxyphylla Chromatography High Pressure Liquid Diarylheptanoids Geography biology Traditional medicine Plant Extracts Organic Chemistry food and beverages Alpinia biology.organism_classification chemistry Organ Specificity Chemistry (miscellaneous) Seeds Kaempferide Molecular Medicine Sesquiterpenes |
| Zdroj: | Molecules; Volume 19; Issue 4; Pages: 4510-4523 Molecules, Vol 19, Iss 4, Pp 4510-4523 (2014) Molecules |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules19044510 |
| Popis: | Plant secondary metabolites are known to not only play a key role in the adaptation of plants to their environment, but also represent an important source of active pharmaceuticals. Alpinia oxyphylla capsular fruits, made up of seeds and pericarps, are commonly used in traditional East Asian medicines. In clinical utilization of these capsular fruits, inconsistent processing approaches (i.e., hulling pericarps or not) are employed, with the potential of leading to differential pharmacological effects. Therefore, an important question arises whether the content levels of pharmacologically active chemicals between the seeds and pericarps of A. oxyphylla are comparable. Nine secondary metabolites present in A. oxyphylla capsular fruits, including flavonoids (e.g., tectochrysin, izalpinin, chrysin, apigenin-4',7-dimethylether and kaempferide), diarylheptanoids (e.g., yakuchinone A and B and oxyphyllacinol) and sesquiterpenes (e.g., nootkatone), were regarded as representative constituents with putative pharmacological activities. This work aimed to investigate the abundance of the nine constituents in the seeds and pericarps of A. oxyphylla. Thirteen batches of A. oxyphylla capsular fruits were gathered from different production regions. Accordingly, an ultra-fast high performance liquid chromatography/quadrupole tandem mass spectrometry (UFLC-MS/MS) method was developed and validated. We found that: (1) the nine secondary metabolites were differentially concentrated in seeds and fruit capsules; (2) nootkatone is predominantly distributed in the seeds; in contrast, the flavonoids and diarylheptanoids are mainly deposited in the capsules; and (3) the content levels of the nine secondary metabolites occurring in the capsules varied greatly among different production regions, although the nootkatone levels in the seeds were comparable among production regions. These results are helpful to evaluating and elucidating pharmacological activities of A. oxyphylla capsular fruits. Additionally, it may be of interest to elucidate the mechanisms involved in the distinct accumulation profiles of these secondary metabolites between seeds and pericarps. |
| Databáze: | OpenAIRE |
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