Isolation from Eucalyptus occidentalis and Identification of a New Kaempferol Derivative that Induces Apoptosis in Human Myeloid Leukemia Cells
| Autor: | Matias Lopez, Fadila Benayache, José Quintana, Jaime Bermejo, Francisco Estévez, Francisco León, Juan Carlos Martín Hernández, Samir Benayache, Samira Benyahia |
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| Rok vydání: | 2004 |
| Předmět: |
Programmed cell death
food.ingredient Pharmaceutical Science Antineoplastic Agents Apoptosis Cytochrome c Group HL-60 Cells DNA Fragmentation Biology Analytical Chemistry chemistry.chemical_compound food Drug Discovery Humans Kaempferols Oleanolic Acid Oleanolic acid Flavonoids Pharmacology Caspase 8 Eucalyptus Molecular Structure Caspase 3 Cytochrome c Organic Chemistry Myeloid leukemia Eucalyptus occidentalis Enzyme Activation Plant Leaves Complementary and alternative medicine chemistry Biochemistry Leukemia Myeloid Algeria Caspases biology.protein Molecular Medicine DNA fragmentation Kaempferol |
| Zdroj: | Journal of Natural Products. 67:527-531 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | In this paper we report the isolation and structural elucidation of a new flavonoid (1) and three known compounds, 6,8-di-C-methylkaempferol 3-methyl ether (2), oleanolic acid, and 2 alpha,3 beta-dihydroxyurs-12-en-28-oic acid, from aerial parts of Eucalyptus occidentalis collected in Algeria. Flavonoids 1 and 2 were used to study their biological activities on the human promyelocytic leukemia cell line, HL-60. Our data show that these compounds induce morphological changes and internucleosomal DNA fragmentation characteristic of apoptotic cell death, which is mediated by caspase-8/caspase-3 activation and cytochrome c release. |
| Databáze: | OpenAIRE |
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