A prospective, population-based study of acute ibuprofen overdose: complications are rare and routine serum levels not warranted
| Autor: | Newell E. McElwee, Douglas E. Rollins, David C. Bradford, Joseph C. Veltri |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Poison Control Centers Adolescent Gastrointestinal Diseases Population Ibuprofen Gastroenterology Sensitivity and Specificity Cohort Studies Predictive Value of Tests Internal medicine Utah medicine Humans Prospective Studies education Prospective cohort study Child Aged education.field_of_study business.industry organic chemicals Infant Newborn Infant Nomogram Middle Aged Prognosis Acute toxicity Anesthesia Predictive value of tests Child Preschool Population Surveillance Toxicity Emergency Medicine Female Nervous System Diseases business medicine.drug Cohort study |
| Zdroj: | Annals of emergency medicine. 19(6) |
| ISSN: | 0196-0644 |
| Popis: | The availability of ibuprofen without a prescription requires assessment of its acute toxicity in the general population. We report results from a prospective study of 329 cases of ibuprofen overdose from a statewide cohort that were reported to our poison center between April 1985 and November 1986; 85 patients had ibuprofen serum concentrations measured. Gastrointestinal disturbances and central nervous system depression were the most common clinical findings (42% and 30% of patients, respectively), but the severity was mild; only one patient had severe symptoms that could be attributed to ibuprofen. Ibuprofen serum concentrations correlated poorly with gastrointestinal symptoms ( r = −.177), central nervous system findings ( r = .176), presence of coingestants ( r = .078), and presence of potentially life-threatening symptoms ( r = .087). We evaluated the usefulness of a previously published nomogram to predict ibuprofen toxicity; the positive predictive value for severe symptoms was 6% for all patients and 0% for patients ingesting ibuprofen alone. We conclude that the frequency of life-threatening complications from ibuprofen overdose is low, the nomogram is not predictive of toxicity, and routine serum concentration determinations are not useful as an adjunct in the management of overdose cases. |
| Databáze: | OpenAIRE |
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